WBC Disorders

WBC Disorders

WBC Disorder

Which viruses have been implicated in virus mediated neutropenia?

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Varicella, measles, rubella, hepatitis A/B

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WBC Disorder

What is the usual interval for cyclic neutropenia?

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21 day but range can be from 12 -36

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WBC Disorder

Which medication used in thyroid disorders can lead to drug induced neutropenia?

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PTU

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WBC Disorders

Which syndrome can myelokathexis be seen in ?

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WHIM

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WBC Disorders

What physical exam feature is notable for patients that have glycogen storage disease Ib?

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Hepatomegaly

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WBC Disorder

What is the inheritance pattern for Dyskeratosis Congenita?

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AR, AD and X-linked

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WBC Disorders

What is the inheritance pattern for Fanconi anemia ?

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Autosomal recessive

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WBC Disorder

What is the inheritance pattern for Schwachman-Diamond Syndrome?

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Autosomal recessive

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WBC Disorder

Is cyclic neutropenia considered mild or severe?

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Can be severe

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WBC Disorder

What is the inheritance pattern of cyclic neutropenia?

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Autosomal dominant

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What is the inheritance pattern of severe congenital neutropenia?

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All possibilities are documented

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WBC Disorder

what is the inheritance pattern for benign familial neutropenia?

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Autosomal dominant

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WBC Disorder

Is ethnic neutropenia considered benign or malignant?
Benign

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WBC Disorders

Can myelocytes be seen with a leukamoid reaction ?

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Yes

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WBC Disorders

What is a typical leukocyte cut-off for a leukamoid reaction ?

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50,000 cells/ uL

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WBC Disorders

Which vasopressor can cause a neutrophilia ?

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Epinephrine

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WBC Disorders

Which medication used in bipolar disease can cause a neutrophilia ?

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Lithium

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WBC Disorders

What is a common cause of neutrophilia in sickle cell patients ?

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Asplenia

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WBC Disorders

What are the most common causes of benign mild neutrophilia in adults ?

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Smoking and Obesity

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WBC Disorders

Which mutation is found in chronic neutrophilic leukemia ?

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CSF3R

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WBC Disorders

Which mutation is associated with chronic eosinophilic leukemia ?

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PDGFRA/B

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WBC Disorders

Which subtype of AML can have eosinophilia ?

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M4

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WBC Disorders

Which cytogenetic change can be seen with eosinophil predominant AML ?

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Inv (16)

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WBC Disorders

What is the most common cause of basophilia ?

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Allergy, not CML

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WBC Disorders

Which WBC subtype is the first to recover after chemotherapy ?

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Monocytes

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WBC Disorders

Which AML subtype is monocytic ?

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M5

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WBC Disorders

Which AML subtype is myelomonocytic ?

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M4

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Which autoimmune disease can commonly have a monocytosis ?

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SLE

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WBC Disorders

Which myeloproliferative neoplasms can present with a monocytosis ?

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Primary myelofibrosis

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WBC Disorders

Is monocytosis in PCV a good risk or poor risk feature ?

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Poor risk

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WBC Disorders

What does monocytosis in primary myelofibrosis indicate ?

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Accelerated disease phase

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WBC Disorders

What can basophilia represent in calreticulin mutated MPN ?

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Evolution to leukemia

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WBC Disorders

Which translocation can be seen in AML with basophilia ?

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t(6;9)(p23;q34)

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WBC Disorders

Which viral infection can cause a lymphopenia ?

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Influenza

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WBC Disorders

Which anti-inflammatory treatment can cause lymphopenia ?

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Corticosteroids

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WBC Disorders

Which type of arthritis can have an associated lymphopenia ?

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Rheumatoid arthritis

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WBC Disorders

Which vitamin deficiency can have an associated lymphopenia ?

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B12

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WBC Disorders

Which infectious agent can present with lymphopenia ?

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Tuberculosis

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WBC Disorders

Which drugs can cause DRESS syndrome ?

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Antiepileptics and antibiotics

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WBC Disorders

Which STD can present with a lymphocytosis ?

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Syphilis

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WBC Disorders

Do RBC inhabiting parasites cause lymphocytosis or neutrohilia ?

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Lymphocytosis

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WBC Disorders

What is commonly seen with eosinopenia ?

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Lymphocytosis

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WBC Disorders

What is a common cause of eosinopenia ?

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Infection

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WBC Disorders

What is the eosinophil cut-off to qualify for hypereosinophilic syndrome ?

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1,500 cells /uL

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WBC Disorders

Which solid tumor risk has been shown correlate with increased levels of eosinophilia ?

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Bladder cancer

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WBC Disorders

Do mast cells or eosinophils express CD117 (Kit) ?

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Mast cells

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