Transplant

Transplant

Flashcards
Transplant Part 5

How do autologous stem cell transplant and maintenance chemotherapy compare in ALL?

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Equivalent

Transplant Part 5
Transplant Part 5

Is there randomized data supporting maintenance chemotherapy following allogeneic stem cell
transplant for ALL?

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No

Transplant Part 5
Transplant Part 5

What is the 3-year leukemia free survival for relapsed and refractory ALL with allogeneic stem cell
transplant without CAR-T ?

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12-25%

Transplant Part 5
Transplant Part 5

Is there are difference in leukemia-free survival in the high- and low-risk relapsed or refractory ALL population status post allogenic stem cell transplant in CR2?

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Yes, low risk is 45% survival while high risk is 15% survival

Transplant Part 5
Transplant Part 5

What is the role of autologous stem cell transplant for relapsed or refractory ALL?

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No role

Transplant Part 5
Transplant Part 5

Are there randomized trials comparing allogeneic stem cell transplant for consolidation chemotherapy
plus TKI versus observation in Ph+ ALL?

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No
2-year overall survival is roughly 60%

Transplant Part 5
Transplant Part 5

What is the role of TKI following allogeneic stem cell transplant for Ph+ ALL?

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Unclear, but 2 years of therapy is generally recommended

Transplant Part 5
Transplant Part 5

What must be taken into consideration when performing an allogeneic stem cell transplant for Fanconi
anemia?

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Lower dose chemotherapy and radiotherapy for conditioning because of high susceptibility to secondary
malignancies

Transplant Part 5
Transplant Part 5

What is a major disadvantage of using autologous stem cell transplant for relapsed follicular lymphoma?

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Significant bone marrow suppression, hence there may be no future role for radio immunotherapy

Transplant Part 5
Transplant Part 5

Is there a role for up-front autologous stem cell transplant for stage III and stage IV follicular lymphoma?

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No

Transplant Part 5
Transplant Part 5

Which relapsed follicular lymphoma patients are ideal candidates for autologous stem cell transplant ?

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Patients who have a history of chemosensitive disease, relapse within the first couple of years of
treatment

Transplant Part 5
Transplant Part 5

Which risk strata patients should be considered for allogeneic stem cell transplantation in
myelodysplastic syndrome?

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High risk and very high risk

Transplant Part 5
Transplant Part 5

What blast percentage increases the incidence of relapse after an allogeneic stem cell transplant in
MDS?

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5%

Transplant Part 5
Transplant Part 5

What TTP-like diagnosis can be made in allogeneic stem cell transplant patients?

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Transplant associated MAHA

Transplant Part 5
Transplant Part 5

Which follicular lymphoma patients are good candidates for allogeneic stem cell transplant?

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Those without a response to autologous stem cell transplant or CART

Transplant Part 5
Transplant Part 5

What is the long-term overall survival advantage to an allogeneic stem cell transplant and autologous
stem cell transplant for relapsed / refractory non-Hodgkin’s lymphoma?

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No difference

Transplant Part 5
Transplant Part 5

Which type of allogeneic stem cell transplant should be considered for follicular lymphoma?

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Non-myeloablative from a primary related donor

Transplant Part 5
Transplant Part 5

What is the role of transplantation for peripheral T-cell lymphoma?

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Controversial

Transplant Part 5
Transplant Part 5

When can one consider allogeneic stem cell transplant for diffuse large B-cell lymphoma?

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Failure of autologous stem cell transplant, CAR-T

Transplant Part 5
Trasnsplant Part 5

What are common exclusion criteria for autologous stem cell transplant in multiple myeloma?

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Age greater than 77, bilirubin greater than 2.0, ECOG 3 or 4 , New York Heart Association stage
III or stage IV heart failure

Trasnsplant Part 5
Transplant Part 5

Which patients can be considered for a tandem transplant?

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Younger patients, 17p deletion, worse than a very good partial response, no other contraindications that
exclude from a transplant within 6 months

Transplant Part 5
Transplant Part 5

What type of packed red blood cell transfusions should be avoided in allogeneic stem cell transplant recipients ?

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Donor-related

Transplant Part 5
Transplant Part 5

What has proven to increase graft failure in aplastic anemia?

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High number of product transfusions prior to the transplant

Transplant Part 5
Transplant Part 5

What is the preservative used in stem cells collected for autologous stem cell transplantation ?

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DMSO

Transplant Part 5
Transplant Part 5

What is a feared complication of ABO mismatch in allogeneic stem cell transplant patients ?

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Delayed immune mediated erythropoiesis ~ PRCA

Transplant Part 5
transfusion medicine

What type of blood product preparation must be performed for allogeneic stem cell transplant and neonate recipients ?

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Gamma radiation, CMV negative matching, and leukocyte reduction

transfusion medicine
transfusion medicine

What type of packed red blood cell transfusion should allogeneic stem cell transplant recipients avoid ?

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Donor-related

transfusion medicine
Platelet Dysfunction

What TTP-like diagnosis can be made in allogeneic stem cell transplant patients?

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Transplant associated MAHA

Platelet Dysfunction
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