Transplant

Transplant

Transplant Part 1

What is the likely diagnosis in a post-allogeneic stem cell transplant patient with hyperbilirubinemia without evidence of venoocclusive disease ?

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Alloimmune Hemolysis

Transplant Part 1
Transplant Part 1

What is the primary difference between major and minor ABO compatibility between donors and recipients in the context of allogeneic stem cell transplant?

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Major–recipient has anti-A and anti-B antibodies
Minor–donor has anti-A and anti-B antibody

Transplant Part 1
Transplant Part 1

what is the standard conditioning regimen for matched sibling transplant in aplastic anemia?

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Cyclophosphamide and fludarabine with or without ATG

Transplant Part 1
Transplant Part 1

After what age is there a significant decline in transplant associated survival for aplastic anemia ?

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40 years old

Transplant Part 1
Transplant Part 1

How do you manage intermediate to high-risk myelofibrosis patients who cannot tolerate allogeneic stem cell transplant ?

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Ruxolitinib

Transplant Part 1
Transplant Part 1

Which MF patients don’t benefit from allogeneic stem cell transplant?

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Low risk and intermediate risk–1

Transplant Part 1
Transplant Part 1

Which drug added in maintenance following autologous stem cell transplant for mantle cell lymphoma shows a trend toward improvement in PFS and OS ?

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Bortezomib , CALGB/Alliance 59909 trial

Transplant Part 1
Transplant Part 1

For patients that receive consolidative autologous stem cell transplant after going into remission with induction chemotherapy for mantle cell lymphoma, what can predict for a 100% 5-year overall survival?

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Low serum beta 2 microglobulin

Transplant Part 1
Transplant Part 1

Is later relapse (> 3 years from CR1) a better or worse prognostic marker in adult B-cell ALL patients that undergo transplant ?

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Better

Transplant Part 1
Transplant Part 1

Is there a higher mortality associated with transplant associated TMA ?

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Yes

Transplant Part 1
Transplant Part 1

Does the addition of DLI to TKI post-transplant for CML improve relapse rates ?

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No

Transplant Part 1
Transplant Part 1

Does the addition of DLI to TKI post-transplant for CML improve relapse rates ?

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No

Transplant Part 1
Transplant Part 1

Should ruxolitinib use be discouraged if allogeneic stem cell transplant is planned for primary myelofibrosis?

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No

Transplant Part 1
Transplant Part 1

Were patients with prior auto-HSCT allowed in the ZUMA-1 trial ?

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Yes, within 12m of transplant

Transplant Part 1
Transplant Part 1

What were the outcomes of the LyMa trial in MCL ?

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maintenance rituximab improves EFS, PFS and OS after transplantation in MCL

Transplant Part 1
Transplant CML

Does the addition of DLI to TKI post-transplant for CML improve relapse rates ?

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No

Transplant CML
Lymphoma

Which drug added in maintenance following autologous stem cell transplant for mantle cell lymphoma shows a trend toward improvement in PFS and OS ?

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Bortezomib , CALGB/Alliance 59909 trial

Lymphoma
MPN

How do you manage intermediate to high-risk myelofibrosis patients who cannot tolerate allogeneic stem cell transplant ?

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Ruxolitinib

MPN
Transplant Part 1

Which antibiotic prophylaxis is recommended for myeloproliferative conditioning regimens?

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Quinolones

Transplant Part 1
Transplant

What are the 3 engraftment time frames for infectious complications in the allogeneic transplant setting?

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Pre-engraftment less than 30 days, early post-engraftment less than on today’s, late post-engraftment
greater than 100 days

Transplant
Transplant

What is the major side effect of busulfan and what prophylaxis is required?

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Seizures, prophylaxis with phenytoin

Transplant
Transplant

Which cytokines are involved in GVHD?

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Interleukin-1, interleukin-2, TNF-gamma

Transplant
Transplant

What is the earliest point in time, post-transplant, that someone can be vaccinated?

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6 months

Transplant
Transplant

Which allogeneic stem cell transplant patients should get growth factor?

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Neutropenia recovery is slow secondary to infection or medication side effect

Transplant
Transplant

Who should get granulocyte growth factor in autologous cell transplant?

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less than 5 million stem cells collected, delayed neutrophil engraftment, notable infection, known
neutropenia causing drugs

Transplant
Transplant

How should stem cell transplant patients be bathed?

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Chlorhexidine

Transplant
Transplant Part 2

What vaginal changes are seen in chronic GVHD?

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Dryness, itching, burning, tenderness

Transplant Part 2
Transplant

What do liver biopsies show for chronic GVHD?

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Lobular persistent hepatitis, small bile ducts, cholestasis

Transplant
Transplant

What do liver biopsies show for chronic GVHD?

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Lobular persistent hepatitis, small bile ducts, cholestasis

Transplant
Transplant

What disease does chronic GVHD liver biopsy resemble?

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Primary biliary cirrhosis

Transplant
Transplant

What major lung diagnoses are seen in chronic GVHD?

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BO and BOOP

Transplant
Transplant

What are the required FEV1 and FEV1/FVC ratios for BO/BOOP?

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FEV1/FVC < 0.70FEV1 < 75%

Transplant
Transplant

What musculoskeletal changes can be seen with chronic GVHD?

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Myositis, arthralgia, fasciitis, cramps, edema

Transplant
Transplant

What complete blood count changes are seen with chronic GVHD?

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Thrombocytopenia, eosinophilia, lymphocytopenia

Transplant
Transplant

Which autoantibodies are seen with chronic GVHD?

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Anti-nucleolar

Transplant
Transplant

What constitutes grade I acute GVHD?

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Stage I skin only without GI or liver involvement

Transplant
Transplant

Which immune cells are responsible for causing acute GVHD?

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T lymphocytes

Transplant
Transplant

Which immune cells are responsible for causing acute GVHD?

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T lymphocytes

Transplant
Transplant

What are some common prophylactic agents used for acute GVHD?

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Cyclosporine, methotrexate, antithymocyte globulin, steroids, MMF

Transplant
Transplant

How can you treat stage I acute GHD?

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Topical steroid and continue with prophylactic cyclosporine

Transplant
Transplant

What is the most common prophylaxis for acute GVHD?

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Cyclosporine plus methotrexate

Transplant
Transplant

What is the therapeutic level of cyclosporine when treating GVHD?

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200-300 mcg/L

Transplant
Transplant

How do you manage ACUTE GVHD if prophylaxis has already ended?

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Restart prophylaxis

Transplant
Transplant

What is starting steroid dose for the treatment of GVHD?

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Methylprednisolone 2 mg/kg daily

Transplant
Transplant

wHICH steroids can be added to therapy if there are notable gastrointestinal symptoms for GVHD?

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Budesonide and beclomethasone

Transplant
Transplant

What steroids can be added to therapy if there are notable gastrointestinal symptoms for GVHD?

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Budesonide and beclomethasone

Transplant
Transplant

What are some second line agents for acute GVHD who fail prednisone?

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MMF, etanercept, photopheresis, mesenchymal stromal cells, sirolimus, pentostatin, ATG

Transplant
Transplant

What is the target of OKT3?

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CD3

Transplant
Transplant

Which monoclonal antibody can be used for acute GVHD?

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IKT3

Transplant
Transplant

What is the difference between prednisone and methylprednisolone and why is intravenous
methylprednisolone preferred for chronic GVHD?

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View Question

Presence of methyl group on methylprednisolone, prevents binding to transcortin and therefore only
bound to albumin, increasing partition coefficient and better delivery to the lung parenchyma

Transplant
Transplant

What are the 4 signs and symptoms of acute GVHD?

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Nausea / vomiting, rash, diarrhea, elevated bilirubin

Transplant
Transplant

What are the risk factors for increased acute GVHD?

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Percent HLA mismatch, female donor with male recipient, conditioning regimen, prophylactic regimen,
graft source

Transplant
Transplant

What is the typical rash pattern / morphology for acute GVHD?

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Maculopapular rash

Transplant
Transplant

What this histology show for acute GVHD of the GI tract?

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Apoptosis of crypt cells

Transplant
Transplant

What defines grades 1-4 hyperbilirubinemia in acute GVHD?

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2-3, 3-6, 6-15, >15

Transplant
Transplant

What defines grade 1-4 acute diarrhea in GVHD?

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502,000 cc, 1000 1500 cc, 1500-2000 cc, greater than 2 L or pain/ileus

Transplant
Transplant

What defines grade 1-4 acute GVHD rash?

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Less than 25%, 25-50%, generalized erythema, bullous lesions

Transplant
Transplant

What Immunoglobulin deficiency can be a manifestation of chronic GVHD?

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IgA deficiency

Transplant
Transplant

What are some rare signs and symptoms can be seen with acute GVHD?

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Lagophthalmos, hemorrhagic conjunctivitis, cytopenias, low immunoglobulin levels, thymic atrophy,
nephrotic syndrome, nephritic syndrome

Transplant
Transplant

Which biomarkers are used with a diagnosis of acute GVHD?

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ST2, Reg3alpha, flow cytometry for CD8/CD30+

Transplant
Transplant

What constitutes grade I acute GVHD?

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Stage I skin only without GI or liver involvement

Transplant
Transplant

What antibiotic is commonly used for infectious prophylaxis in allogeneic stem cell transplant?

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Bactrim

Transplant
Transplant

When should Bactrim prophylaxis be started with respect to allogeneic stem cell transplant?

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After the 30 day mark given its potential for myelosuppression

Transplant
Transplant

What is the minimum duration of the PCP prophylaxis for allogeneic stem cell transplant?

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6 months, more than 6 months required if any evidence of GVHD

Transplant
Transplant

Which 3 yeast species are the most common infectious organisms in allogenic stem cell transplant patients ?

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Aspergillus, Candida, PCP

Transplant
Transplant

Which yeast / mold species are more commonly seen in early and late allogeneic stem cell transplant?

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Candidate = early
PCP = late

Transplant
Transplant Part 3

What is the likely cause of pre-engraftment hepatitis?

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Venoocclusive disease / sinusoid obstructive syndrome

Transplant Part 3
Transplant

What is the difference between early and late post-engraftment hemorrhagic cystitis?

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Early secondary to chemotherapy–Cytoxan, ifosfamide, busulfan, radiation
Late secondary to viral infection – BK virus, polyoma virus, adenovirus

Transplant
Transplant

What is a common pulmonary side effect of autologous stem cell transplant that is diffuse in pattern?

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Engraftment syndrome

Transplant
Transplant

What are the 3 most common causes of diarrhea during the early engraftment period ?

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Magnesium side effects, C. difficile, typhlitis

Transplant
Transplant

What are the 2 major risk factors for pre-engraftment infection and allogeneic stem cell transplant?

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Neutropenia and mucositis

Transplant
Transplant

What are the 3 different engraftment periods for allogeneic stem cell transplant?

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Early = less than 3 weeks
Intermediate= 3 weeks to 3 months
Late = > 3 months

Transplant
Transplant

What defines steroid failure in acute GVHD?

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No response or progression by day 7

Transplant
Transplant

What is a typical cyclosporine serum concentration target?

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200-300 ng/mL during days 1 through 30 then taper down to 100-200 ng/mL days 30 to 90 and taper off
If there is no evidence of GVHD.

Transplant
Transplant

When should cyclosporine be added for GVHD therapy?

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WHen there is resistance to prednisone

Transplant
Transplant

How can you prevent venoocclusive disease in high-risk allogeneic stem cell transplant?

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Defibrotide

Transplant
Transplant

Which vaccines can be given 6 months post allogeneic stem cell transplant?

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DTaP, inactivated polio, HiB, hepatitis B, pneumococcal

Transplant
Transplant

What are some contraindications to live vaccine use in allogeneic stem cell transplant patients?

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Active immunosuppressive medications, less than 2 years from transplant, chronic GVHD

Transplant
Transplant

What are the advantages to single cord transplant?

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Low platelet recovery time, low chronic grade 3 / 4 GVHD, low acute grade 3 / 4 GVHD, improved 1 year
overall survival

Transplant
Transplant

When can live vaccines be administered after allogeneic stem cell transplantation?

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2 years posttransplant

Transplant
Transplant

What is the preferred conditioning regimen for related donor allogeneic stem cell transplant?

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Busulfan plus Cytoxan

Transplant
Transplant

What is the pathophysiologic cause of autoimmune hemolysis following allogeneic stem cell transplant?

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Passenger lymphocyte syndrome

Transplant
Transplant

Which conditioning regimen has the highest risk factor for the development of venoocclusive disease?

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Cytoxan and busulfan

Transplant
Transplant

Which conditioning regimen is recommended for AML?

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Busulfan plus Cytoxan

Transplant
Transplant

What is the time course of passenger lymphocyte syndrome in ABO mismatched transplant?

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7-14 days

Transplant
Transplant

Which chemotherapy agents increase the risk of developing venoocclusive disease?

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Cyclophosphamide and busulfan

Transplant
Transplant

What are the advantages and disadvantages of single versus double cord transplant?

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Single–low platelet recovery time, grade 2, 3, 4 acute and chronic GVHD, improved overall survival
Double – Increased recovery times for older adults

Transplant
Transplant

What immunoglobulin changes are seen with chronic GVHD?

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Low IgA

Transplant
Transplant

What autoimmune conditions can be seen as part of chronic GVHD?

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Neuropathy, cardiomyopathy, nephrotic syndrome, polyserositis, polymyositis, myasthenia gravis,
vasculitis, central nervous system demyelination, encephalitis

Transplant
Transplant

Which gastrointestinal tract features are pathognomonic for chronic GVHD?

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webs, strictures or stenosis in the upper one half of the esophagus

Transplant
Transplant

What is the recommended scoring used by the National Institute of Health for GVHD severity ?

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Mild = at most 2 sites
Moderate = greater than or equal to 3 sites
Severe= major disability

Transplant
Transplant

Which virus can cause hemorrhagic cystitis?

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BK virus and adenovirus

Transplant
Transplant

What are the 5 signs / symptoms of VOD and SOS?

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Right upper quadrant pain, jaundice, elevated bilirubin, ascites, hepatomegaly

Transplant
Transplant

What are the major risk factors for developing VOD and SOS?

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Underlying liver disease, allogeneic transplant, leukemia, high-dose cyclophosphamide

Transplant
Transplant

What agents should be added to the conditioning regimen for haploidentical/ matched unrelated donor
transplant to reduce the incidence of acute GVHD ?

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ATG

Transplant
Transplant

What is the black box warning for MMF?

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Central nervous system toxicity = PML

Transplant
Transplant

How does MMF work?

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Inhibits inosine monophosphate Dehydrogenase (IMPDH) and leads to low purine synthesis in
leukocytes

Transplant
Transplant

Which conditioning regimen should sirolimus be used with?

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Myeloablative busulfan given high SOS/VOD

Transplant
Transplant

What endocrine abnormality can be seen with sirolimus?

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Elevated cholesterol

Transplant
Transplant

What is a major visceral organ side effect of sirolimus?

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The liver

Transplant
Transplant

Which monoclonal antibody can be used in the post allogeneic transplant setting as prophylaxis to
prevent GVHD?

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View Question

Rituximab

Transplant
Transplant

What are the risk factors for developing chronic GVHD?

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View Question

Increasing percentage of HLA mismatch, increasing age of donor and recipient, female donor male
recipient, alloimmunization, stem cell source peripheral blood > bone marrow, history of acute GVHD,
donor lymphocyte infusion use, underlying splenectomy, positive CMV, positive EBV

Transplant
Transplant

What percentage of patients have skin GVHD?

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67%

Transplant
Transplant

What is the classic skin change seen with chronic GVHD?

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Lichen planus sclerotic changes with hyper or hypopigmentation

Transplant
Transplant

What ophthalmologic changes can be seen with chronic GVHD?

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Dryness, cataracts, corneal epithelial staining conjunctivae will hyperemia, chemosis, corneal epithelial
sloughing

Transplant
Transplant

What nail changes are seen with chronic GVHD?

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Ridging, splitting, brittleness, onycholysis

Transplant
Transplant Part 4

Which conditioning regimen is preferred for myelofibrosis transplant ?

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View Question

Fludarabine/busulfan

Transplant Part 4
Transplant

Is ruxolitnib used in acute and / or chronic GVHD ?

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View Question

Acute

Transplant
Transplant

If there are any data to support the use of pretransplant checkpoint inhibition for AML ?

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View Question

Yes, improvements in acute GVHD reported especially if post transplant cyclophosphamide used

Transplant
Transplant

When is the earliest stem cell transplant patients can receive the Flu vaccine?

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4 month

Transplant
Transplant

What are some methods to reduce EBV viral load?

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Rituximab, low immunosuppression, EBV specific cytotoxic T cells

Transplant
Transplant

Which transplant patients are at an elevated risk for CMV reactivation?

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View Question

Umbilical cord transplant, T-cell depleted allograft, alemtuzumab therapy, HLA mismatched allograft

Transplant
Transplant

How can you manage CMV positive and CMV mismatched transplant recipients with regards to
prophylaxis?

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View Question

Weekly CMV virus PCR and if positive start antiviral agent

Transplant
Transplant

What is the treatment for VZV IgG allo-HSCT negative patients that have exposure to chickenpox?

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Varizig

Transplant
Transplant

Which prophylaxis should be used for varicella prophylaxis?

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View Question

Acyclovir or valacyclovir

Transplant
Transplant

How long is herpesvirus prophylaxis given? for allogeneic transplant patient

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View Question

Until engraftment or mucositis resolution

Transplant
Transplant

What are prophylactic options for herpes virus during allogeneic transplantation ?

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View Question

Acyclovir or valacyclovir

Transplant
Transplant

What defines HSV seropositivity?

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Notable IgG+ for herpes

Transplant
Transplant

What is the general time course for VOD in Allo-HSCT patients?

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View Question

3 weeks

Transplant
Transplant

How long should varicella prophylaxis be given in IgG+ VZV patients undergoing allogeneic or autologous
stem cell transplant?

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View Question

>/=1 year

Transplant
Transplant

How long is herpesvirus prophylaxis given ?

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30 days after transplant

Transplant
Transplant

How long should anti-hepatitis B therapy be given in transplant patients?

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View Question

Autologous = 6 months
Allogeneic = 6 months after immunosuppressive therapy is held

Transplant
Transplant

Does renal or liver injury require dose modifications for tacrolimus?

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View Question

Liver injury

Transplant
Transplant

Which hematologic disease can occur secondary to cyclosporine or FK506?

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View Question

TTP

Transplant
Transplant

Which antihypertensive therapy should be used to treat cyclosporine and his hypertension?

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View Question

Calcium channel blockers

Transplant
Transplant

What are common side effects with cyclosporine?

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View Question

Renal injury, elevated bilirubin, hypertension, hyperglycemia, low triglyceride levels, headache, seizures

Transplant
Transplant

Which category of medications should be avoided while using cyclosporine?

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View Question

Antifungal agents

Transplant
Transplant

Which enzyme metabolizes cyclosporine ?

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View Question

Cytochrome P450

Transplant
Transplant

Which protein does tacrolimus target?

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View Question

FKBP

Transplant
Transplant

Which protein does cyclosporine inhibit?

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View Question

Cyclophillin binds cyclopsorin and blocks calcineurin

Transplant
Transplant

What is an alternative mechanism for methotrexate?

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View Question

Metabolism of methotrexate to polyglutamate ligation, leading to increase toxicity to DHFR

Transplant
Transplant

What is the mechanism of methotrexate?

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View Question

Inhibition of dihydropyridine reductase leading to reduced folate levels, increased oxidative state,
inability to reduce, hence no methyltransferase capability

Transplant
Transplant

What is the typical GVHD prophylaxis regimen cocktail?

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View Question

Cyclosporine, methotrexate, steroids

Transplant
Transplant

Which electrolyte changes are common with cyclosporine?

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View Question

Hypomagnesemia

Transplant
Transplant

What are the 2 general classes of immunosuppressive prophylaxis in GVHD?

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View Question

Nonspecific–steroids and methotrexate
T-cell specific: cyclosporine, tacrolimus, MMF, OKT3, antithymocyte globulin, rituximab

Transplant
Transplant

What is the starting dose for methylprednisolone for acute GVHD?

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View Question

2 mg/kg

Transplant
Transplant

What prophylaxis for venoocclusive disease is given for autologous stem cell transplant ?

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View Question

Aspirin or heparin

Transplant
Transplant

What other complications can occur with venoocclusive disease?

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View Question

Pulmonary and kidney injury

Transplant
Transplant

Which virus commonly causes hemorrhagic cystitis in the early post-engraftment ?

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View Question

BK virus

Transplant
Transplant

What complications can adenovirus cause in allogeneic stem cell transplant?

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View Question

More commonly – Upper respiratory tract infection, pneumonitis, diarrhea, hemorrhagic colitis,
nephritis, hemorrhagic cystitis
less commonly – encephalitis, myocarditis, hepatitis, multiorgan failure

Transplant
Transplant

What is the common noninfectious cause of diarrhea in early stem cell transplant?

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View Question

Magnesium supplementation

Transplant
Transplant

Is HSV more likely to cause mucositis or esophagitis?

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View Question

Mucositis

Transplant
Transplant Part 5

How do autologous stem cell transplant and maintenance chemotherapy compare in ALL?

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View Question

Equivalent

Transplant Part 5
Transplant Part 5

Is there randomized data supporting maintenance chemotherapy following allogeneic stem cell
transplant for ALL?

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View Question

No

Transplant Part 5
Transplant Part 5

What is the 3-year leukemia free survival for relapsed and refractory ALL with allogeneic stem cell
transplant without CAR-T ?

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View Question

12-25%

Transplant Part 5
Transplant Part 5

Is there are difference in leukemia-free survival in the high- and low-risk relapsed or refractory ALL population status post allogenic stem cell transplant in CR2?

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View Question

Yes, low risk is 45% survival while high risk is 15% survival

Transplant Part 5
Transplant Part 5

What is the role of autologous stem cell transplant for relapsed or refractory ALL?

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View Question

No role

Transplant Part 5
Transplant Part 5

Are there randomized trials comparing allogeneic stem cell transplant for consolidation chemotherapy
plus TKI versus observation in Ph+ ALL?

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View Question

No
2-year overall survival is roughly 60%

Transplant Part 5
Transplant Part 5

What is the role of TKI following allogeneic stem cell transplant for Ph+ ALL?

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View Question

Unclear, but 2 years of therapy is generally recommended

Transplant Part 5
Transplant Part 5

What must be taken into consideration when performing an allogeneic stem cell transplant for Fanconi
anemia?

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View Question

Lower dose chemotherapy and radiotherapy for conditioning because of high susceptibility to secondary
malignancies

Transplant Part 5
Transplant Part 5

What is a major disadvantage of using autologous stem cell transplant for relapsed follicular lymphoma?

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View Question

Significant bone marrow suppression, hence there may be no future role for radio immunotherapy

Transplant Part 5
Transplant Part 5

Is there a role for up-front autologous stem cell transplant for stage III and stage IV follicular lymphoma?

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View Question

No

Transplant Part 5
Transplant Part 5

Which relapsed follicular lymphoma patients are ideal candidates for autologous stem cell transplant ?

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View Question

Patients who have a history of chemosensitive disease, relapse within the first couple of years of
treatment

Transplant Part 5
Transplant Part 5

Which risk strata patients should be considered for allogeneic stem cell transplantation in
myelodysplastic syndrome?

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View Question

High risk and very high risk

Transplant Part 5
Transplant Part 5

What blast percentage increases the incidence of relapse after an allogeneic stem cell transplant in
MDS?

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View Question

5%

Transplant Part 5
Transplant Part 5

What TTP-like diagnosis can be made in allogeneic stem cell transplant patients?

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View Question

Transplant associated MAHA

Transplant Part 5
Transplant Part 5

Which follicular lymphoma patients are good candidates for allogeneic stem cell transplant?

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View Question

Those without a response to autologous stem cell transplant or CART

Transplant Part 5
Transplant Part 5

What is the long-term overall survival advantage to an allogeneic stem cell transplant and autologous
stem cell transplant for relapsed / refractory non-Hodgkin’s lymphoma?

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View Question

No difference

Transplant Part 5
Transplant Part 5

Which type of allogeneic stem cell transplant should be considered for follicular lymphoma?

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View Question

Non-myeloablative from a primary related donor

Transplant Part 5
Transplant Part 5

What is the role of transplantation for peripheral T-cell lymphoma?

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View Question

Controversial

Transplant Part 5
Transplant Part 5

When can one consider allogeneic stem cell transplant for diffuse large B-cell lymphoma?

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View Question

Failure of autologous stem cell transplant, CAR-T

Transplant Part 5
Trasnsplant Part 5

What are common exclusion criteria for autologous stem cell transplant in multiple myeloma?

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View Question

Age greater than 77, bilirubin greater than 2.0, ECOG 3 or 4 , New York Heart Association stage
III or stage IV heart failure

Trasnsplant Part 5
Transplant Part 5

Which patients can be considered for a tandem transplant?

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View Question

Younger patients, 17p deletion, worse than a very good partial response, no other contraindications that
exclude from a transplant within 6 months

Transplant Part 5
Transplant Part 5

What type of packed red blood cell transfusions should be avoided in allogeneic stem cell transplant recipients ?

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View Question

Donor-related

Transplant Part 5
Transplant Part 5

What has proven to increase graft failure in aplastic anemia?

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View Question

High number of product transfusions prior to the transplant

Transplant Part 5
Transplant Part 5

What is the preservative used in stem cells collected for autologous stem cell transplantation ?

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View Question

DMSO

Transplant Part 5
Transplant Part 5

What is a feared complication of ABO mismatch in allogeneic stem cell transplant patients ?

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View Question

Delayed immune mediated erythropoiesis ~ PRCA

Transplant Part 5
transfusion medicine

What type of blood product preparation must be performed for allogeneic stem cell transplant and neonate recipients ?

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View Question

Gamma radiation, CMV negative matching, and leukocyte reduction

transfusion medicine
transfusion medicine

What type of packed red blood cell transfusion should allogeneic stem cell transplant recipients avoid ?

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View Question

Donor-related

transfusion medicine
Platelet Dysfunction

What TTP-like diagnosis can be made in allogeneic stem cell transplant patients?

View Answer
View Question

Transplant associated MAHA

Platelet Dysfunction
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