The Flashcard Demo

CNS Tumors Demo

Which gene mutation analysis is required to stratify glioblastoma?

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MGMT

CNS Tumors Demo
CNS Tumors Demo

Which histologic subtypes of testicular germ cell tumor are brain metastases most common with?

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Choriocarcinoma

CNS Tumors Demo
CNS Tumors Demo

For an asymptomatic meningioma that is grade I, what is the ideal mode of management?

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Observation

CNS Tumors Demo
CNS Tumors Demo

What radiation field should be considered for ependymoma with + mets ?

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Craniospinal radiation

CNS Tumors Demo
GBM Demo

Has an OS been demonstrated for carmustine wafers in recurrent/refractory GBM ?

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Yes, Brem et al. 1995

GBM Demo
Transfusion Medicine Demo

In which 2 scenarios would cryoprecipitate be preferred over fresh frozen plasma for acute bleeding?

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Cirrhosis and Coumadin-related bleeding because cryoprecipitate contains factor VIII, factor XIII, fibrinogen and von Willebrand factor

Transfusion Medicine Demo
Transfusion Medicine Demo

How can you treat purpura fulminans in newborn with protein S deficiency?

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FFP or Protein S concentrate

Transfusion Medicine Demo
Transfusion Medicine Demo

What is the infection risk with cryoprecipitate?

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10-fold increase because of 10 different donors

Transfusion Medicine Demo
Transfusion Medicine Demo

What is removed with the process of PRBC washing ?

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plasma, WBC and platelets

Transfusion Medicine Demo
Transfusion Medicine Demo

What minimum increase in the platelet concentration defines platelet refractoriness after transfusing 2 units?

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less than 10,000

Transfusion Medicine Demo
Anemia Demo

What are the severe consequences of C. difficile colitis and hemolytic anemia?

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Liver and kidney failure

Anemia Demo
Thrombocytopenia Demo

How quickly can one generally see a response in ITP with the use of TPO mimetics ?

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7-14 days

Thrombocytopenia Demo
Anemia Demo

What is the time course for Hapten/drug adsorption mediated AIHA?

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7-10 days

Anemia Demo
Thrombocytopenia Demo

What is a very rare central nervous system side effects that may occur with rituximab treatment for ITP?

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Progressive multifocal leukoencephalopathy

Thrombocytopenia Demo
Anemia Demo

Which opiates are preferred for acute pain crisis in sickle cell anemia?

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Short acting opiates, avoid NSAIDs

Anemia Demo
Anemia Demo

What helps leg ulcers besides supportive care in sickle cell anemia?

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Hydroxyurea and packed red blood cells

Anemia Demo
Transfusion Medicine Demo

Which 2 factors are not present in thawed plasma after 5 days?

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Factor V and factor VIII

Transfusion Medicine Demo
Pharmacology Demo

What are 2 very rare but serious side effects with granulocyte growth factor?

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Splenic rupture and acute respiratory distress syndrome

Pharmacology Demo
Hemophilia Demo

What is a poor prognostic marker for hemophilia patients?

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Severe hemophilia, + inhibitor, no response to IPI

Hemophilia Demo
Hemophilia Demo

If recombinant factor VIII replacement is not available, which blood products can be used for hemophilia A and hemophilia B?

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Hemophilia A–cryoprecipitate
Hemophilia B–fresh frozen plasma

Hemophilia Demo
Ovarian Cancer Demo

How do you manage borderline epithelial ovarian cancer following surgical staging ?

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Observation or treatment as a low-grade epithelial

Ovarian Cancer Demo
Ovarian Cancer Demo

What did the QUADRA trial assess ?

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Niraparib in BRCA mutated and wild type serous ovarian cancer after third line progression

Ovarian Cancer Demo
Endometrial Cancer Demo

How do you manage high risk endometrial cancer in hereditary non-polyposis colon cancer female
patients?

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Endometrial sampling and also consider hysterectomy

Endometrial Cancer Demo
Melanoma Demo

Which biomarker is both prognostic and predictive for metastatic melanoma with regards to treatment response to ipilimumab and nivolumab ?

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Elevated LDH

Melanoma Demo
Melanoma Demo

What percent grade 3 or 4 toxicity can be expected when combining BRAF/MEK inhibitors and PDL1 targeting therapy ?

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75% Pyrexia and LFT elevations

Melanoma Demo
Melanoma Demo

What is the most common immune related adverse event with nivolumab in metastatic melanoma ?

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Dermatitis

Melanoma Demo
Cervical Cancer Demo

Did the GOG240 trial show an OS advantage to adding bevacizumab to carboplatin + paclitaxel for cervical cancer ?

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Indeterminate, but appears to have an OS advantage

Cervical Cancer Demo
Transplant Demo

What is the difference in progression free survival for intermediate and standard risk myeloma versus
poor risk status post autologous stem cell transplant ?

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24 months versus 12 months

Transplant Demo
Lymphoma Demo

When would you consider ibrutinib for MZL ?

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Only after CD20 based therapy

Lymphoma Demo
Lymphoma Demo

What is the preferred treatment for stage I and stage II diffuse large B-cell lymphoma?

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3 cycles of R–CHOP plus localized radiotherapy

Lymphoma Demo
Lymphoma Demo

What is the V in the R-CVEP regimen for r/r DLBCL ?

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Vorinostat

Lymphoma Demo
MZL Demo

What are the first, second, third and fourth – line treatments for splenic marginal zone lymphoma?

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First-line treatment is hepatitis C treatment
Second line treatment of splenectomy
Third line treatment is rituximab-based chemotherapy
Fourth line treatment is ibrutinib if refractory to CD20 based therapy

MZL Demo
Transfusion Medicine Demo

Which platelet surface antigen causes post-transfusion purpura?

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HPA-1a

Transfusion Medicine Demo
Hodgkin’s Disease Demo

Which regimen has shown superiority over other regimens in a phase 3 randomized trial in r/r HD ?

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None

Hodgkin’s Disease Demo
MCL Demo

Does the national cancer center network recommend upper endoscopy and colonoscopy as part of the initial workup for newly diagnosed mantle cell lymphoma?

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Only in highly suspicious cases involving the gastrointestinal tract

MCL Demo
Transfusion Medicine Demo

What are the 5 factors that cryoprecipitate is enriched with?

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Factor VIII, factor XIII, fibrinogen, fibroNECTIN, von Willebrand factor

Transfusion Medicine Demo
Lymphoma Demo

What was the purpose of the RESORT study in MZL ?

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Randomized phase 3 clinical trial, Retreatment rituximab (weekly ×4) at every progression versus maintenance rituximab (every 3 months)

Lymphoma Demo
Hemophilia Demo

What is a long-term management option for Hemophilia A patients with a notable inhibitor for hemophilia?

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ITI

Hemophilia Demo
MDS Demo

Which biological pathway does luspatercept target ?

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TGF-Beta

MDS Demo
MDS Demo

Has the addition of lenalidomide to azacitidine shown to improve ORR or CR ?

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No

MDS Demo
MDS Demo

What were the results of the SUPPORT trial in MDS ?

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The addition of eltrombopag worsened platelet recovery

MDS Demo
Thrombocytopenia Demo

Can patients with hepatitis C without cirrhosis develop thrombocytopenia?

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Yes

Thrombocytopenia Demo
Prostate Cancer Demo

What did the ENZAMET trial show in prostate cancer ?

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Superior OS with enzalutamide versus ADT + bicalutamide in first line metastatic prostate cancer

Prostate Cancer Demo
Thrombocytopenia Demo

How long can drug-induced thrombocytopenia take to develop for patients that are naïve to the offending drug?

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1-2 weeks

Thrombocytopenia Demo
Thrombocytopenia Demo

In patients with pregnancy related thrombocytopenia, that require neuraxial anesthesia, what threshold is recommended ?

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More than 80,000/mcL

Thrombocytopenia Demo
Thrombocytopenia Demo

What common cardiovascular complication can result in thrombotic microangiopathy with thrombocytopenia?

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Severe hypertension

Thrombocytopenia Demo
Head and Neck Cancer Demo

What are the TNM criteria for stage I/II squamous cell carcinoma of the lip?

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T<4 cm, NO lymphadenopathy, no local invasion

Head and Neck Cancer Demo
Head and Neck Cancer Demo

What advantage is there for panitumumab over cetuximab for relapsed or refractory metastatic head
and neck cancer?

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None

Head and Neck Cancer Demo
Head and Neck Cancer Demo

Which phase 3 trial has been the only one to demonstrate an improvement in OS with the cetuximab in the definitive setting for H&N CA ?

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IMCL-9815, comparator arm was radiotherapy

Head and Neck Cancer Demo
CML Demo

Do PPI and H2 Receptor antagonists reduce the efficacy of dasatinib ?

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No

CML Demo
CML Demo

Has a superior 12month MMR rate been shown with bosutinib versus imatinib in CML ?

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Yes, BFORE trial

CML Demo
CML Demo

Which phase 3 trial determined the best TKI for CML blast crisis ?

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None

CML Demo
T-cell PLL Demo

Which opportunistic infection is most severe when using Alemtuzumab for T-cell PLL?

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CMV

T-cell PLL Demo
CLL Demo

What did the GALTON trial assess in newly diagnosed CLL ?

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Obinutuzumab – FC Obinutuzumab –Bendamustine, single arm , Higher ORR with OB than OFC

CLL Demo
cholangiocarcinoma demo

Which VEGFR targeting TKI has shown activity in advanced cholangiocarcinoma ?

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Regorafenib

cholangiocarcinoma demo
Anal Cancer Demo

What risk factor increases the risk of developing anal cancer 40 fold?

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HIV

Anal Cancer Demo
HCC Demo

What did the REACH-2 trial assess ?

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Ramucirumab in advanced HCC following progression on sorafenib when AFP > ng/mL

HCC Demo
HCC Demo

Does TACE prior to liver transplant for HCC result in inferior post-transplant survival ?

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No

HCC Demo
Rectal Cancer Demo

What options do patients with initial lower one third rectal tumors have to avoid abdominoperineal
resection?

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Preoperative concurrent chemoradiotherapy to try and convert to LAR

Rectal Cancer Demo
Anal Cancer Demo

When is surgery employed for anal cancer?

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Salvage therapy only

Anal Cancer Demo
Anemia Demo

How can you distinguish spherocytosis from pyruvate kinase deficiency?

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Normal osmotic fragility test in pyruvate kinase versus hereditary spherocytosis

Anemia Demo
Transplant Demo

Does renal or hepatic injury require dose modifications for tacrolimus?

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Hepatic injury

Transplant Demo
Transplant Demo

Which transplant patients are at an elevated risk for CMV reactivation?

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Umbilical cord transplant, T-cell depleted allograft, alemtuzumab therapy, HLA mismatched allograft

Transplant Demo
Transplant Demo

What defines grades 1-4 hyperbilirubinemia in acute GVHD?

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2-3, 3-6, 6-15, >15

Transplant Demo
Neutrophil Disorders Demo

How severe can myeloperoxidase deficiency be?

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Mild to no symptoms

Neutrophil Disorders Demo
Renal Cell Carcinoma Demo

Does the addition of lenvatinib to everolimus improve OS in second line advanced RCC ?

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No

Renal Cell Carcinoma Demo
Adrenal Cancer Demo

Is there activity with PDL1 targeting therapies in metastatic adrenocortical carcinoma?

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Yes

Adrenal Cancer Demo
Platelet Dysfunction Demo

Which test for HIT uses a radioactive agent?

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Serotonin release assay – uses carbon 14

Platelet Dysfunction Demo
Mastocytosis Demo

Is there any phase 3 data to support the use of any particular TKI in systemic mastocytosis ?

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No

Mastocytosis Demo
Colon Cancer Demo

Which subset of patients have been shown to have major pathologic responses to neoadjuvant immunotherapy ?

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MMR-d/MSI-H patients, NICHE trial showed 100% response rate with 95% major pathologic response

Colon Cancer Demo
CLL Demo

What was the purpose of the PROLONG trial in CLL ?

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Assess the efficacy or ofatumumab maintenance versus observation in relapsed CLL after reinduction

CLL Demo
Multiple Myeloma Demo

What is one of the most challenging hematologic side effects with selinexor?

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Grade 4 thrombocytopenia has been reported in more than 25% of patients

Multiple Myeloma Demo
Multiple Myeloma Demo

Which myeloma agents have shown activity in POEMS ?

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lenalidomide plus dexamethasone in a phase 2 trial, 60% PFS at 3 years

Multiple Myeloma Demo
Multiple Myeloma Demo

What did the FOCUS trial assess in r/r MM ?

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randomized phase III study of carfilzomib vs low-dose corticosteroids with optional cyclophosphamide in relapsed and refractory multiple myeloma

Multiple Myeloma Demo
Multiple Myeloma Demo

What was the structure of the IFM 2009 trial for MM ?

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Phase 3 trial of RVd x 3 cycles then either RVd for 5 more or melphalan + auto-HSCT, both with Rev maintenance x 1 year

Multiple Myeloma Demo
Thyroid Cancer Demo

Is there randomized data supporting the use of sunitinib in progressive medullary thyroid cancer ?

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No

Thyroid Cancer Demo
ALL Demo

Is any particular TKI used in r/r Ph+ B-cell ALL supported by phase 3 data ?

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No, all phase 2

ALL Demo
GIST Demo

Which patient subsets have inferior responses to imatinib in GIST ?

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cKIT Exon 9

GIST Demo
Renal Cell Carcinoma Demo

Is there phase 1, 2, and or 3 data to support the use of regorafenib in advanced RCC ?

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Phase II

Renal Cell Carcinoma Demo
Gastric Cancer Demo

What type of surgery was offered in the CLASSIC trial for gastric cancer ?

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D2

Gastric Cancer Demo
Colon Cancer Demo

Can the use of neo-adjuvant FOLFOX + cetuximab improve liver resection and OS in liver-only metastases from colon cancer ?

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Yes, shown in phase 3 trial

Colon Cancer Demo
Colon Cancer Demo

Has an been demonstrated with the use of ziv-aflibercept in advanced colorectal cancer ?

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Yes, combined with FOLFOX

Colon Cancer Demo
Lung Cancer Demo

Is there data to support the use of pembrolizumab + pemetrexed maintenance after induction chemo/pembro ?

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Yes, KEYNOTE-189 trial

Lung Cancer Demo
Lung Cancer Demo

Which phase 3 trial has demonstrated the superiority of any second-line TKI in EGFR mutated advanced NSCLC ?

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None

Lung Cancer Demo
Lung Cancer Demo

Which chemo doublet has shown superiority over cisplatin/etoposide for first-line extensive stage small cell lung cancer ?

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Cisplatin/irinotecan

Lung Cancer Demo
Lung Cancer Demo

What did the Impower133 trial assess in small cell lung cancer ?

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Atezolizumab added to carboplatin/etoposide as first-line treatment in extensive stage small cell lung cancer

Lung Cancer Demo
Breast Cancer Demo

Does the addition of ixabepilone to capecitabine after progression on a taxane and anthracycline improve PFS in triple negative breast cancer ?

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Yes

Breast Cancer Demo
Breast Cancer Demo

Can palbociclib be used in men with breast cancer ?

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Yes

Breast Cancer Demo
Breast Cancer Demo

What was the most common reported grade 3 / 4 AE with trastuzumab-deruxtecan in the DESTINY-Breast-01 trial ?

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Neutropenia

Breast Cancer Demo
Breast Cancer Demo

What did the TRINITI-1 trial assess for HR+ Her2- breast cancer ?

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Everolimus + ribociclib + exemestane in patients that had progressed on CDK4/6 + AI with 1 year PFS 33% , ASCO 2019 #1016

Breast Cancer Demo
Pharmacology Demo

what is the target of tociluzimab used for cytokine storm in CAR-T therapy ?

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IL-6R

Pharmacology Demo
Germ Cell Tumor Demo

What is the only feature that makes a seminoma intermediate risk?

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Non-pulmonary visceral metastases

Germ Cell Tumor Demo
AML Demo

When would you consider a repeat induction regimen for AML versus a salvage regimen?

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View Question

Older patients, young patient with low burden refractory disease, hypocellular marrow, 10- 20% blasts,
High tumor burden primary refractory disease likely requires salvage therapy

AML Demo
ALL Demo

What is the mortality with induction difference between patients less than 60 and older than 60 for
HyperCVAD ?

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2% versus 15%

ALL Demo
ALL Demo

Which enzyme should be tested prior to treating with 6-MP?

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TPMT

ALL Demo
Esophageal Cancer Demo

Which TNM stage Esophageal cancer qualifies for resection or ablation without chemotherapy or
radiotherapy?

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pTis and pT1a N0 M0

Esophageal Cancer Demo
Thymoma Demo

What is the recommended adjuvant therapy for R1 or R2 thymoma versus thymic cancer?

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Thymoma cyclophosphamide + cis-platinum + doxorubicin
Thymic cancer carboplatin + paclitaxel

Thymoma Demo
Cold Agglutinin Demo

What is the definition of a cold agglutinin ?

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IgM antibody to I or i

Cold Agglutinin Demo
MPN

Is ruxolitinib safe in pregnancy ?

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No

MPN
ALL

Can tisagenlecleucel be used for Ph+ r/r B-cell ALL ?

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Yes , can be used for both Ph+ and Ph –

ALL
ALL

Which portion of the BCR-ABL fusion protein should be sequenced for TKI refractory cases ?

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ABL1 kinase domain

ALL
AML

What comprises FLAG-IDA ?

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Fludarabine, cytarabine, G-CSF and idaurubicin

AML
CNS Tumors

what treatment option is available for patients with primary CNS lymphoma without any more systemic therapeutic options ?

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CNS Tumors
Central Nervous System

What systemic chemotherapy is effective for leptomeningeal breast cancer?

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Methotrexate

Central Nervous System
Platelet Dysfunction

Which chemotherapy agents have been associated with drug-induced thrombotic microangiopathy?

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Gemcitabine and oxaliplatin

Platelet Dysfunction
Platelet Dysfunction

Does the ITP incidence increase with age?

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View Question

Yes

Platelet Dysfunction
Germ Cell Tumor

What are 3 high-risk features of nonseminomatous germ cell tumor?

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Lymphovascular invasion or embryonal carcinoma components, T3 primary tumor, T4 primary tumor

Germ Cell Tumor
CNS Tumors

Which CDK 4/6 inhibitor has the best CNS penetration for HR+ Her2- metastatic breast cancer ?

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View Question

abemaciclib

CNS Tumors

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