Pancreatic cancer

Pancreatic Cancer

Pancreatic Cancer

What did the POLO trial assess ?

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Maintenance olaparib for germline BRCA-mutated metastatic pancreatic cancer

Pancreatic Cancer
Pancreatic Cancer

Is there phase III data to support the use of induction gemcitabine/XRT for unresectable pancreatic cancer ?

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Yes

Pancreatic Cancer
pancreatic cancer

Is there a survival advantage to mFOLFIRINOX in the adjuvant setting for pancreatic cancer ?

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Yes

pancreatic cancer
pancreatic cancer

What did the ESPAC-4 trial assess for pancreatic cancer ?

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Gemcitabine plus capecitabine in the adjuvant setting for pancreatic cancer

pancreatic cancer
Pancreatic Cancer

What did the MPact trial assess in pancreatic cancer ?

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The addition of nab-paclitaxel to single agent gemcitabine in first-line advanced pancreatic cancer

Pancreatic Cancer
Pancreatic Cancer

What was the comparator arm in PRODIGE/ACCORD-4 ?

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Gemcitabine

Pancreatic Cancer
Pancreatic Cancer

Which trial established the efficacy of FOLFIRINOX for advanced pancreatic cancer ?

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PRODIGE/ACCORD-4

Pancreatic Cancer
Pancreatic Cancer

Is there phase III data to support the use of gemcitabine in the first-line setting for advanced pancreatic cancer ?

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Yes

Pancreatic Cancer
Pancreatic Cancer

What lab features portend a worse OS for first line metastatic pancreatic cancer treated with gemcitabine and nab-paclitaxel ?

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Elevated CA 19-9 and Neutrophil to Lymphocyte ratio

Pancreatic Cancer
pancreatic cancer

What did the NAPOLI-1 trial assess in pancreatic cancer ?

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Liposomal irinotecan added to 5-FU/Lv vs Liposomal irinotecan monotherapy vs 5-FU/Lv in gemcitabine refractory metastatic pancreatic cancer

pancreatic cancer
pancreatic cancer

What did the CONKO-003 trial assess in advanced pancreatic cancer ?

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Efficacy of OLF in gemcitabine refractory pancreatic cancer

pancreatic cancer
pancreatic cancer

What is the main difference between OLF and FOLFOX ?

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No bolus 5-FU in FOLFOX

pancreatic cancer
Pancreatic Cancer

Is there randomized phase III data supporting the use of single-agent nab-paclitaxel in the second line setting for advanced pancreatic cancer ?

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No, only phase II

Pancreatic Cancer
Pancreatic Cancer

What did the MPACT trail assess in metastatic pancreatic cancer ?

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Gemcitabine + nab-paclitaxel versus gemcitabine

Pancreatic Cancer
Pancreatic Cancer

Did the POLO trial enroll germline and / or somatic BRCA mutations for pancreatic cancer ?

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Germline

Pancreatic Cancer
Pancreatic Cancer

Which BRCA mutation is laparib active in for pancreatic cancer ?

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Both BRCA1/2

Pancreatic Cancer
Pancreatic Cancer

What did the POLO trial assess in metastatic pancreatic cancer ?

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Olaparib in BRCA mutated pancreatic cancer after progression in platinum based therapy

Pancreatic Cancer
Pancreatic Cancer

What did the NAPOLI-1 trial assess in metastatic pancreatic cancer ?

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Liposomal irinotecan + 5FU/Lv versus 5FU/Lv

Pancreatic Cancer
Pancreatic Cancer

What did the PRODIGE 4 / ACCORD 11 evaluate in pancreatic cancer ?

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FOLFIRINOX vs gemcitabine in the metastatic setting

Pancreatic Cancer
Pancreatic Cancer

What did the ESPAC-4 trial evaluate in pancreatic cancer ?

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Addition of capecitabine to gemcitabine in the adjuvant setting

Pancreatic Cancer
Pancreatic Cancer

What is the difference between FOLFIRINOX and FOLFOXIRI ?

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FOLFOXIRI has no bolus 5-FU and irinotecan dose is loweered from 180 to 165mg/m2

Pancreatic Cancer
Pancreatic cancer

How would you stage IV pancreatic cancer with microsatellite instability?

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PD-1 directed therapy

Pancreatic cancer
Pancreatic cancer

What is the black box warning for liposomal irinotecan?

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Severe bone marrow suppression with neutropenic sepsis

Pancreatic cancer
Pancreatic cancer

What is the bilirubin cut off for FOLFIRINOX use ?

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1.5 x ULN

Pancreatic cancer
Pancreatic cancer

How many new cases of pancreatic cancer are diagnosed every year in the United States ?

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55,000

Pancreatic cancer
Pancreatic cancer

Absence of the fat plane between which major vessels is a contraindication to resection for
pancreatic cancer?

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Inferior vena cava, aorta, celiac trunk, hepatic artery

Pancreatic cancer
Pancreatic cancer

What is the maximum encasement of the superior mesenteric vein or portal vein that can
make a pancreatic cancer resectable?

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180°

Pancreatic cancer
Pancreatic cancer

What is the 5 year survival rate for stage III pancreatic cancer?

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11%

Pancreatic cancer
Pancreatic cancer

What is the sensitivity range for CA 19-9 for diagnosing pancreatic cancer?

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70-92%

Pancreatic cancer
Pancreatic cancer

Where is a Sister Mary Joseph node located tumor?

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Periumbilical area

Pancreatic cancer
Pancreatic cancer

What percentage of pancreatic cancers arise in the pancreatic head?

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Roughly 65%

Pancreatic cancer
Pancreatic cancer

What is the most common sign of pancreatic Cancer?

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Jaundiced–55%

Pancreatic cancer
Pancreatic cancer

What is the most common symptom with regards to pancreatic cancer?

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Asthenia–85%

Pancreatic cancer
Pancreatic cancer

What percentage of pancreatic cancer is our endocrine origin?

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5%

Pancreatic cancer
Pancreatic cancer

What percentage of pancreatic neoplasms are adenocarcinoma?

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85%

Pancreatic cancer
Pancreatic cancer

Can you employ a stop and go strategy with Oxaliplatin in stage IV pancreatic cancer?

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Yes

Pancreatic cancer
Pancreatic cancer

Is Gem/Abraxane on a 21 or 28 day cycle?

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28 day

Pancreatic cancer
Pancreatic cancer

Erlotinib is approved for stage IV pancreatic cancer along with which agent?

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Gemcitabine

Pancreatic cancer
Pancreatic cancer

Which clinical trial established the role of FOLFIRINOX and stage IV pancreatic cancer?

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ACCORD 11 trial

Pancreatic cancer
Pancreatic cancer

What is the emesis risk with FOLFIRINOX?

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High

Pancreatic cancer
Pancreatic cancer

What is a rare pulmonary side effects of oxaliplatin?

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Pulmonary fibrosis

Pancreatic cancer
Pancreatic cancer

How is liposomal irinotecan approved by the FDA for use in pancreatic cancer ?

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In combination with 5-FU/LV after gemcitabine progression

Pancreatic cancer
Pancreatic cancer

What percentage of newly diagnosed pancreatic cancer cases are resectable upfront?

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15%

Pancreatic cancer
Pancreatic cancer

What level evidence is there for adjuvant chemotherapy use following resection of pancreatic
cancer?

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Grade 1A

Pancreatic cancer
Pancreatic cancer

For good performance status patients, following resection of pancreatic cancer, which
regimen is recommended?

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FOLFIRINOX

Pancreatic cancer
Pancreatic cancer

In the adjuvant setting for pancreatic cancer, patients cannot tolerate FOLFIRNOX, which
regimen is recommended?

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Gemcitabine plus Capecitabine

Pancreatic cancer
Pancreatic cancer

Which 2 drugs were used in the ESPAC-4 trial?

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Gemcitabine and capecitabine

Pancreatic cancer
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