Ovarian cancer

Ovarian Cancer

Ovarian cancer

Which intravenous chemotherapy should be used for adjuvant ovarian cancer?

View Answer
View Question

Carboplatinum and paclitaxel for 6 cycles ideally

Avoid cis-platinum, docetaxel, and avoid going past 6 cycles

Ovarian cancer
Ovarian cancer

How do you manage optimally and suboptimally debulked ovarian cancer in the adjuvant setting?

View Answer
View Question

Optimal carboplatin and paclitaxel plus intraperitoneal chemotherapy
Suboptimal carboplatinum and paclitaxel only no intraperitoneal chemotherapy
This still remains a contentious issue

Ovarian cancer
Ovarian cancer

Which ovarian germ cell tumors can be managed with observation following surgery?

View Answer
View Question

Dysgerminoma stage IA or stage I, grade 1 immature teratoma

Ovarian cancer
Ovarian cancer

What is a unique treatment option for malignant sex cord tumor?

View Answer
View Question

Radiotherapy

Ovarian cancer
Ovarian cancer

What is a unique treatment option for low-grade serous endometrioid ovarian cancer ?

View Answer
View Question

Endocrine therapy

Ovarian cancer
Ovarian cancer

What are 2 important features of mucinous ovarian cancer?

View Answer
View Question

Elevated CEA
Treatment is the same as colon cancer regimens, FOLFOX,FOLFIRI

Ovarian cancer
Ovarian cancer

What is the difference between the number of cycles of adjuvant chemotherapy for clear-cell stage IA –
stage IC versus stage II, stage III, stage IV?

View Answer
View Question

Stage IA, B, C use 3-6 cycles of carboplatinum and paclitaxel
Stage 2, 3, 4 – use 6 cycles of carboplatin and paclitaxel

Ovarian cancer
Ovarian cancer

Which stages of carcinosarcoma and mixed mullerian tumor can avoid adjuvant chemotherapy?

View Answer
View Question

None – all of them should get it

Ovarian cancer
Ovarian cancer

What are 7 different types of histology for ovarian cancer besides epithelial?

View Answer
View Question

Carcinosarcoma, clear cell, mucinous, low-grade serosa, borderline epithelial, malignant sex cord,
malignant germ cell tumor

Ovarian cancer
Ovarian cancer

Which maintenance can be offered to platinum sensitive ovarian cancer stage IV patients?

View Answer
View Question

Bevacizumab or niraparib

Ovarian cancer
Ovarian cancer

How many cycles of adjuvant chemotherapy can you offer stage IV ovarian cancer patients?

View Answer
View Question

3-6 cycles of carboplatin plus paclitaxel

Ovarian cancer
Ovarian cancer

How do you manage an Ovarian dermoid cyst?

View Answer
View Question

Observation

Ovarian cancer
Ovarian cancer

Which subtype of ovarian cancer does not respond to chemotherapy?

View Answer
View Question

Clear-cell

Ovarian cancer
Ovarian cancer

What hormone do granulosa cells secrete?

View Answer
View Question

Inhibin

Ovarian cancer
Ovarian cancer

What kind of tumor is a Thecoma?

View Answer
View Question

Sex cord tumor

Ovarian cancer
Ovarian cancer

Which subtype of ovarian cancer can evolve into an endometrial cancer?

View Answer
View Question

Granulosa

Ovarian cancer
Ovarian Cancer Part 2

What phase was the QUADRA trial ?

View Answer
View Question

Phase II

Ovarian Cancer Part 2
Ovarian Cancer

What did the QUADRA trial assess ?

View Answer
View Question

Niraparib in BRCA mutated and wild type serous ovarian cancer after third line progression

Ovarian Cancer
Ovarian Cancer

What did the MITO-11 trial assess in advanced ovarian cancer ?

View Answer
View Question

Improvement in PFS with the addition of pazopanib to paclitaxel

Ovarian Cancer
Ovarian Cancer

What did the AURELIA trial asses in advanced ovarian cancer ?

View Answer
View Question

Improvement in PFS when bevacizumab is added to liposomal doxorubicin or paclitaxel or topotecan

Ovarian Cancer
Ovarian Cancer

What did the GOG-0218 trial assess in advanced ovarian cancer ?

View Answer
View Question

The addition of bevacizumab to carboplatin/paclitaxel with or without maintenance bevacizumab – showed superior PFS

Ovarian Cancer
Ovarian Cancer

What did the SOLO1 trial assess in advanced ovarian cancer ?

View Answer
View Question

Phase 3 trial of maintenance olaparib maintenance following platinum based first line chemotherapy in newly diagnosed serous ovarian cancer in BRCA1/2 mutated patients

Ovarian Cancer
Ovarian Cancer

What did the SOLO2 trial assess in advanced ovarian cancer ?

View Answer
View Question

Phase 3 trial of maintenance olaparib for platinum sensitive relapsed serous ovarian cancer in BRCA1/2 mutated patients

Ovarian Cancer
Ovarian Cancer

What did the MITO-2 trial assess in advanced serous ovarian carcinoma ?

View Answer
View Question

Carboplatin + liposomal doxorubicin versus carboplatin + paclitaxel in first-line advanced serous ovarian cancer

Ovarian Cancer
Ovarian Cancer

Was a survival advantage demonstrated in the NRG/GOG213 trial ?

View Answer
View Question

Yes

Ovarian Cancer
Ovarian Cancer

What did the NRG/GOG213 trial assess for ovarian cancer ?

View Answer
View Question

Carboplatin/paclitaxel with or without bevacizumab as well as maintenance in recurrent platinum sensitive serous ovarian cancer with or without secondary cytoreduction

Ovarian Cancer
Ovarian Cancer

Has an OS been demonstrated in the OCEANS trial ?

View Answer
View Question

No

Ovarian Cancer
Ovarian Cancer

What did the OCEANS trial assess in ovarian cancer ?

View Answer
View Question

Phase III trial of bevacizumab or placebo added to carbo/gem in platinum sensitive relapse recurrent ovarian cancer

Ovarian Cancer
Ovarian cancer

What is another name for low-grade epithelial ovarian cancer?

View Answer
View Question

Low malignant potential tumor

Ovarian cancer
Ovarian cancer

How do you manage borderline epithelial ovarian cancer following surgical staging ?

View Answer
View Question

Observation or treatment as a low-grade epithelial

Ovarian cancer
Ovarian cancer

What are 2 types of teratoma seen in ovarian cancer?

View Answer
View Question

Immature and benign

Ovarian cancer
Ovarian cancer

Which first line chemotherapy regimen is used following diagnosis of stage II yolk sac tumor?

View Answer
View Question

Bleomycin etoposide cis-platinum

Ovarian cancer
Ovarian cancer

How can you manage grade 2 stage II ovarian germ cell tumor with persistent disease following
bleomycin / etoposide / cis-platinum?

View Answer
View Question

New chemotherapy regimen such as ITP or VIP with or without autologous stem cell transplant consolidation

Ovarian cancer
Ovarian cancer

What defines optimal versus suboptimal ovarian cancer debulking?

View Answer
View Question

Less than or equal to 1 cm residual disease

Ovarian cancer
Ovarian cancer

With defines stage III and stage IV ovarian cancer ?

View Answer
View Question

Stage III lymph node or peritoneal involvement
Stage IV liver, lung and other non-abdominal tissue

Ovarian cancer
Ovarian cancer

If a patient shows a response to bevacizumab, carboplatin and paclitaxel for platinum sensitive ovarian
cancer, what should be done next?

View Answer
View Question

Bevacizumab maintenance

Ovarian cancer
Ovarian cancer

Which criteria would prompt one to use adjuvant chemotherapy for stage I and stage II ovarian cancer?

View Answer
View Question

grade 2 tumor, clear cell histology, stage IC or stage II, high-grade, otherwise observation only

Ovarian cancer
Ovarian cancer

Which endocrine agents can be used for platinum resistant ovarian cancer without symptoms?

View Answer
View Question

Tamoxifen, letrozole, fulvestrant

Ovarian cancer
Ovarian cancer

For platinum resistant ovarian cancer does topotecan , paclitaxel or doxorubicin show the highest overall
response rate ?

View Answer
View Question

All are equal

Ovarian cancer
Ovarian cancer

What single agent chemotherapy/biologic is available for stage IV ovarian cancer with resistance to
platinum or taxanes?

View Answer
View Question

Anthracyclines or bevacizumab

Ovarian cancer
Ovarian cancer

What oral agent should be considered for BRCA mutated ovarian cancer?

View Answer
View Question

PARP inhibitors

Ovarian cancer
Ovarian cancer

What chemotherapy agent can be used in platinum resistant ovarian cancer?

View Answer
View Question

Paclitaxel

Ovarian cancer
Ovarian cancer

What is a major contraindication to bevacizumab treatment and stage IV ovarian cancer?

View Answer
View Question

Bowel obstruction

Ovarian cancer
Ovarian cancer

How do you treat ovarian cancer with prior platinum treatment with relapse after 6 months?

View Answer
View Question

Retreatment with single agent platinum

Ovarian cancer
Ovarian cancer

How do you treat relapsed platinum resistant ovarian cancer with no symptoms?

View Answer
View Question

Endocrine therapy

Ovarian cancer
Ovarian cancer

How do you treat relapsed ovarian cancer with rising CEA but no change on CT scan?

View Answer
View Question

Observation only

Ovarian cancer
Ovarian cancer

What is the definition of platinum sensitive ovarian cancer?

View Answer
View Question

Response lasting for at least 6 months

Ovarian cancer
Ovarian cancer

How do you treat ovarian dysgerminoma or immature teratoma?

View Answer
View Question

Dysgerminoma
stage I – observation
Stage 2, 3, 4 – chemotherapy with bleomycin etoposide cisplatin for 4 cycles
Immature teratoma – bleomycin etoposide cis-platinum for 3-4 cycles for stages 1-4
Yolks sac tumor – bleomycin etoposide cisplatin for 3-4 cycle stage 1-4

Ovarian cancer
Ovarian cancer

How do you treat adjuvant carcinosarcoma or Mullerian tumor?

View Answer
View Question

Same as epithelial

Ovarian cancer
Ovarian cancer

What is another name for mixed mullerian tumor ?

View Answer
View Question

Carcinosarcoma

Ovarian cancer
Ovarian cancer

What is stage I ovarian cancer upstaged to if there are positive peritoneal washings?

View Answer
View Question

Stage IC

Ovarian cancer
Ovarian cancer

Which stage ovarian cancer patients can have adjuvant observation ?

View Answer
View Question

Stage IA and stage IB without high risk features

Ovarian cancer
Ovarian cancer

Which subtype of ovarian cancer tends to present as low-grade and low stage ?

View Answer
View Question

Endometrial

Ovarian cancer
Ovarian cancer

Is retroperitoneal lymphadenopathy in ovarian cancer stage III or stage IV?

View Answer
View Question

Stage III

Ovarian cancer
Ovarian cancer

Do inguinal lymph nodes stage ovarian cancer as stage III or stage IV?

View Answer
View Question

Stage IV

Ovarian cancer
Ovarian cancer

Which 3 tumor markers can be used for ovarian cancer ?

View Answer
View Question

CA-125, CEA, HE4

Ovarian cancer
Ovarian cancer

What maintenance is offered for stage III and stage IV ovarian cancer status post surgery and adjuvant
therapy?

View Answer
View Question

None
chemotherapy, bevacizumab, VEGF inhibitors and PARP inhibitor

Ovarian cancer
Ovarian cancer

What is the definition of dose dense adjuvant chemotherapy for ovarian cancer that has been
suboptimally debulked?

View Answer
View Question

Paclitaxel every 7 days, carboplatinum every 3 weeks for 15 weeks

Ovarian cancer
Ovarian cancer

Which non-taxane regimen can be used with carboplatinum?

View Answer
View Question

Carboplatinum plus doxorubicin but a lower number of available tries for meta- analyses

Ovarian cancer
en_USEnglish