Mixed Hematology Flashcards

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Anemia

When should pneumonia vaccine start for sickle cell anemia patients?

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PVC-13 (conjugate) ASAP and PPSV23 (polysaccharide) – after age 2

Anemia
Anemia

Which 2 treatments that are used for warm and AIHA do not have a role in cold AIHA ?

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Splenectomy and steroids

Anemia
Multiple myeloma

What type of antibody is daratumumab?

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IgG kappa

Multiple myeloma
Bleeding Diatheses

What mediates to binding the factor VIII and factor IX to the platelet surface?

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Factor Va

Bleeding Diatheses
Bleeding Diatheses

What can lead to a false negative when a diagnosis is suspicious for hemophilia?

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Mild hemophilia with normal PTT because it is an acute phase reactant

Bleeding Diatheses
Neutrophil Disorders

Which pathogens are chronic granulomatous disease patients most susceptible to?

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Catalase positive bacteria including staph aureus, nocardia, Borrelia

Neutrophil Disorders
Bleeding Diatheses

How can women acquire hemophilia?

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Nonrandomized chromosome inactivation

Bleeding Diatheses
Multiple myeloma

What defines a complete response and stringent complete response for multiple myeloma?

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Complete response negative immunofixation in the serum and urine, no plasmacytoma, less than 5%
plasma cells in the bone marrow
Stringent complete response is a complete response pulses normal light chain ratio plus a bone marrow
biopsy light chain ratio 4:1

Multiple myeloma
Multiple myeloma

Which imaging study should be avoided in myeloma patients with a GFR less than 30?

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Gadolinium because of fibrosis risk

Multiple myeloma
Anemia

When should you check a G6PD level to confirm a diagnosis?

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After the hemolytic event has finished – 4-6 weeks later

Anemia
Pharmacology

Which cytogentic change is seen with etoposide related AML?

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MLL

Pharmacology
CML

What percentage Philadelphia chromosome corresponds to major, minor, minimal, and complete
cytogenetic response?

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Major = 0%
Partial = 5- 35%
Minor = 35-65%
Minimal = 65-95%

CML
Lymphoma

Has a superiority of SMILE or DDGP been demonstrated in newly diagnosed advanced NK/T-cell lymphoma ?

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Yes, DDGP has shown to be superior in the Chinese CTTNKTL-III/IV trial

Lymphoma
AML

Which other translocation is similar to t(15;17) and what is its relation to ATRA?

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t(11;17) , low response, seen in 1% of APL cases , poor prognosis

AML
AML

Which cytogenetic changes are good risk in AML?

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Inversion 16, deletion 9q, t(16;16), t(8;21)

AML
CML

What were the results of the STIM1 trial at 5 years in CML ?

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38% without molecular recurrence versus 43% at 6 months

CML
AML

How can you consolidate a late relapse AML who achieves a second remission?

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Allogeneic stem cell transplant

AML
CLL

What are the 2 options for patients with relapsed CLL who have high toxicity to first-line chemo-based
treatment?

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Ibrutinib or idelalisib + rituximab (less popular) or venetoclax

CLL
Lymphoma

What is the DDGP regimen used in advanced NK/T-cell lymphoma ?

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Dex, cisplatin, PEG-Asparaginase

Lymphoma
CLL

With defines stages 0-4 of Rai staging system?

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0–leukocytosis only
1–leukocytosis and lymphadenopathy
2–leukocytosis and lymphadenopathy or hepatosplenomegaly
3- leukocytosis and anemia and/or lymphadenopathy–splenomegaly/hepatomegaly
4- leukocytosis and thrombocytopenia and/or hepatosplenomegaly or lymphadenopathy

CLL
Thrombosis

What does tissue factor and factor VIIa complex form?

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Xa-ase complex

Thrombosis
Transplant

How do you manage ACUTE GVHD if prophylaxis has already ended?

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Restart prophylaxis

Transplant
Thrombosis

What are the 2 available protein C concentrates?

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USA – 3 factor -2,9,10
Europe/USA-4 factor – 2,7,9,10

Thrombosis
Rare Disorders HLH

Should stem cell transplantation be considered in adults with an identified genetic cause of HLH in remission?

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yes

Rare Disorders HLH
ALL

How can you distinguish chronic myeloid leukemia blast crisis transformation from Philadelphia
chromosome positive ALL?

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Unable to distinguish

ALL
ALL

Was there an improvement in 2-year EFS with the addition of rituximab to induction chemo with B-cell ALL ?

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Yes

ALL
Transplant

Which conditioning regimen is recommended for AML?

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Busulfan plus Cytoxan

Transplant
Transplant

Which virus can cause hemorrhagic cystitis?

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BK virus and adenovirus

Transplant
Rare Disorders Porphyria

Are there neurovisceral complications in patients with PCT ?

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Very rare – essentially absent

Rare Disorders Porphyria
Rare Disorders HLH

Can a stem cell transplant can be used if the patient is still actively hemophacytosing ?

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No

Rare Disorders HLH
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