Mixed Chapters Oncology Flashcards

Mixed Chapters

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Ovarian Cancer

What did the SOLO1 trial assess in advanced ovarian cancer ?

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Phase 3 trial of maintenance olaparib maintenance following platinum based first line chemotherapy in newly diagnosed serous ovarian cancer in BRCA1/2 mutated patients

Ovarian Cancer
Ovarian Cancer

What did the SOLO2 trial assess in advanced ovarian cancer ?

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Phase 3 trial of maintenance olaparib for platinum sensitive relapsed serous ovarian cancer in BRCA1/2 mutated patients

Ovarian Cancer
Germ Cell Tumor

Which chemotherapy agents are active in relapsed / refractory testicular germ cell tumors?

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Cis-platinum, ifosfamide, vinblastine, paclitaxel, gemcitabine, oxaliplatin, bleomycin

Germ Cell Tumor
Head and Neck Cancer

Which Phase III trial showed a survival advantage in first-line metastatic SCC of the Head & Neck ?

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EXTREME

Head and Neck Cancer
Cervical Cancer

Which phase III trial has demonstrated an OS advantage in advanced cervical cancer ?

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None

Cervical Cancer
GIST

Which TKI has randomized second – line data in GIST refractory to imatininb ?

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Sunitinib

GIST
Ovarian Cancer

What did the NRG/GOG213 trial assess for ovarian cancer ?

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Carboplatin/paclitaxel with or without bevacizumab as well as maintenance in recurrent platinum sensitive serous ovarian cancer with or without secondary cytoreduction

Ovarian Cancer
Prostate Cancer

What did the PROSELICA trial assess in metastatic prostate cancer ?

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Non-inferiority of cabazitaxel 20mg/m2 versus 25mg/m2

Prostate Cancer
GIST

What did the ENESTg1 trial assess ?

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Imatinib versus nilotinib as first line treatment in advanced GIST with imatinib being superior

GIST
Germ Cell Tumor

Which histology for germ cell tumors looks like a fried egg?

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Seminoma

Germ Cell Tumor
Central Nervous System

What systemic chemotherapy is effective for leptomeningeal breast cancer?

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Methotrexate

Central Nervous System
Head and neck cancer

What is the standard of care for stage III nasopharyngeal carcinoma?

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Concurrent chemoradiotherapy plus bilateral neck irradiation

Head and neck cancer
HCC

What agent is used for radio embolization in liver cancer?

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Yttrium-90

HCC
Central Nervous System

Which intrathecal chemotherapy is good for leptomeningeal Her2 breast cancer?

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Methotrexate and trastuzumab

Central Nervous System
Colon cancer

What was the comparator arm in the ALEX clinical trial for stage IV colon cancer?

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capecitabine monotherapy

Colon cancer
Gastric cancer

What is the primary difference between adjuvant gastric cancer therapy in the United States versus
Japan?

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Japan – S1 chemotherapy for 1 year in the adjuvant setting
United States – concurrent chemoradiotherapy in the adjuvant setting

Gastric cancer
HCC

What is characteristic of HCC on arterial and venous phase imaging?

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Enhanced arterial imaging and delayed venous washout

HCC
HCC

What benefit is there to adding doxorubicin to sorafenib?

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None

HCC
Breast cancer

What are the 2 important neoadjuvant trials for pertuzumab?

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NEOSPHERE – trastuzumab versus trastuzumab plus per to Zometa versus trastuzumab plus rituximab
plus paclitaxel in the neoadjuvant setting resulted in a patient complete pathologic response of 46%
TRYPHAENA – FEC + TP + taxane vs TCHP in the neoadjuvant setting

Breast cancer
Colon cancer

Is there a difference in survival outcomes between open and laparoscopic surgery for colon cancer?

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No

Colon cancer
Cancer Unknown Primary

What diagnostic molecular tests can be ordered for cancer of unknown primary?

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Next generation sequencing, mismatch repair deficiencies, PD–L1 staining, Her2 staining,
microsatellite instability testing

Cancer Unknown Primary
Rectal Cancer

If patients get low anterior resection first without chemotherapy, is there still a role for adjuvant
chemotherapy?

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Yes

Rectal Cancer
Biostatistics

What is the difference between a hazard ratio and a relative risk ?

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Relative risk is a snapshot in time, usually the end of a study while the hazard ratio is the dynamic result

Biostatistics
Pharmacology

What is the target of Irinotecan?

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Topoisomerase 1

Pharmacology
Colon cancer

Which prophylactic surgery should be considered in female patients with HNPCC?

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Total abdominal hysterectomy with bilateral salpingo-oophorectomy

Colon cancer
Melanoma

Which type of biopsy should be performed on a suspicious melanoma lesion to establish a diagnosis?

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Punch biopsy

Melanoma
Anal Cancer

When is surgery employed for anal cancer?

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Salvage therapy only

Anal Cancer
Rectal Cancer

What options do patients with initial lower one third rectal tumors have to avoid abdominoperineal
resection?

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Preoperative concurrent chemoradiotherapy to try and convert to LAR

Rectal Cancer
GIST and Sarcoma

How can you approach an unresectable GIST ?

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Neoadjuvant treatment then reimaging

GIST and Sarcoma
Pharmacology

Is there a creatinine clearance cut off for using capecitabine?

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30

Pharmacology
Rectal cancer

What are the features of T3 and T4 rectal cancer?

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T3 tumors pass the muscularis propria and invade into the peri-colorectal tissue
T4 tumor penetrate to the surface of the visceral peritoneum

Rectal cancer
Ovarian cancer

What defines optimal versus suboptimal ovarian cancer debulking?

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Less than or equal to 1 cm residual disease

Ovarian cancer
Prostate Cancer

Is there an improvement in overall survival with the use of radiation 223?

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Yes

Prostate Cancer
Germ Cell Tumor

What is the primary treatment for brain metastases from testicular cancer?

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Chemotherapy but also consider radiotherapy and surgery

Germ Cell Tumor
Thyroid Cancer

Which TKIs are active in metastatic differentiated thyroid cancer?

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Lenvatinib, sorafenib, cabozantinib, pazopanib, vandetaninb, Sunitinib

Thyroid Cancer
Thyroid Cancer

What is the purpose of rhTSH administration prior to radioactive iodine treatment?

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To increased TSH levels, hence causing increased iodine uptake

Thyroid Cancer
bladder cancer

Which chemotherapy backbone is ideal for bladder cancer?

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Cis-platinum

bladder cancer
prostate cancer

When would you consider a CT scan or MRI versus a bone scan for prostate cancer?

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T3 disease, T4 disease, T1-T2 and nomogram with at least a 10% lymph node metastatic probability

prostate cancer
Neuroendocrine tumors

What isotype is used for somatostatin scans?

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Indium-111 tagged somatostatin

Neuroendocrine tumors
Lung Cancer

What alternating chemotherapy regimens are active in extensive stage small cell lung cancer?

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CAV/PE and CDE/VMP

Lung Cancer
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