Lymphoma

Lymphoma

Lymphoma Part 1

Lymphoma Part 1

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Lymphoma Part 1

Lymphoma Part 1
Lymphoma

What are commonly utilized salvage regimens for R/R DLBCL ?

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R–GV / R-CEPP / R-CEOP /ibrutinib/ R-B /polatuzumab vedotin plus bendamustine /lenalidomide plus rituximab

Lymphoma
Lymphoma

Which regimens are preferred for activated B-cell R/R DLBCL if CAR-T is not an option?

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Ibrutinib plus rituximab or lenalidomide plus rituximab

Lymphoma
Lymphoma

What mechanistic category is selinexor in ?

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SINE -selective inhibitor of nuclear export

Lymphoma
Lymphoma

How is selinexor administered for R/R DLBCL ?

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60 mg orally on days 1 and 3 every week

Lymphoma
Lymphoma

What is the overall response rate of selinexor for MR/DLBCL ?

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Approximately 30%

Lymphoma
Lymphoma

What is the median duration of response with selinexor in patients with R/R DLBCL who achieved a complete response ?

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23 months

Lymphoma
Lymphoma

How common is a complete response with selinexor for r/r DLBCL ?

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12%

Lymphoma
Lymphoma

What is the most common hematologic grade 3 and higher adverse events seen with selinexor ?

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Thrombocytopenia seen in approximately 45%

Lymphoma
Lymphoma

Which electrolyte abnormality is of concern when administering selinexor ?

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Hyponatremia

Lymphoma
Lymphoma

What is the biologic target of loncastuximab tesirine ?

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CD19

Lymphoma
Lymphoma

What is the target of loncastuximab tesirine ?

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CD19

Lymphoma
Lymphoma

What kind of chemotherapeutic agent is the payload for loncastuximab tesirine ?

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Alkylating agent

Lymphoma
Lymphoma

What is the overall response rate with loncastuximab tesirine R/R DLBCL ?

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48% with 24% complete response

Lymphoma
Lymphoma

What is the target of Tafasitamab ?

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CD19

Lymphoma
Lymphoma

What is Tafasitamab combined with during treatment for R/R DLBCL?

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Lenalidomide

Lymphoma
Lymphoma

What is the complete response rate with Tafasitamab plus lenalidomide in R/R DLBCL?

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Approximately 45%

Lymphoma
Lymphoma

What is the most common grade 3/4 adverse events seen with Tafasitamab plus lenalidomide?

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Cytopenias in particular neutropenia

Lymphoma
Lymphoma

What is the complete response rate with Blinatumomab for R/R DLBCL ?

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19%

Lymphoma
Lymphoma

What is a complete response rate with brentuximab vedotin and CD30 positive R/R DLBCL ?

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Approximately 17%

Lymphoma
Lymphoma

What is the therapeutic target of polatuzumab vedotin ?

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CD79b

Lymphoma
Lymphoma

What is polatuzumab vedotin combined with as part of its regulatory approval by the FDA for R/R DLBCL ?

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Bendamustine plus rituximab

Lymphoma
Lymphoma

What is a complete response rate of polatuzumab vedotin plus bendamustine plus rituximab and R/R DLBCL ?

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40%

Lymphoma
Lymphoma

When is allogeneic stem cell transplant utilized for patients with R/R DLBCL ?

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Lack of access to CAR-T/poor stem cell mobilization for autologous transplant/relapse after autologous transplant

Lymphoma
Lymphoma

What type of conditioning regimen is generally utilized for allogeneic HCT for R/R DLBCL ?

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Nonmyeloablative or reduced intensity conditioning

Lymphoma
Lymphoma

Which 3 CAR-T agents have the most data for R/R DLBCL ?

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Axicabtagene ciloleucel / Tisagenlecleucel / lisocabtagene maraleucel

Lymphoma
Lymphoma

What are the reported ORR and CR in the ZUMA-1 trial with Axicabtagene ciloleucel R/R DLBCL?

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82 and 54 %

Lymphoma
Lymphoma

How common is grade 3/4 neutropenia with Axicabtagene ciloleucel ?

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78%

Lymphoma
Lymphoma

Which patient characteristic predicts for severe neurologic events when utilizing Axicabtagene ciloleucel for R/R DLBCL?

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Age above 65

Lymphoma
Lymphoma

What is the complete response rate reported with Tisagenleucel in R/R DLBCL ?

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40%

Lymphoma
Lymphoma Part 1

Lymphoma Part 1

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Lymphoma Part 1

Lymphoma Part 1
Lymphoma

Does MYD88 (WT) or MYD88(L265P) have a higher incidence of aggressive lymphoma transformation ?

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WT

Lymphoma
lymphoma

What were the results of the IELSG30 trial in primary CNS lymphoma ?

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MTX + Ara-C has superior CR rates compared to MTX

lymphoma
lymphoma

What were the results of the IELSG32 trial in primary CNS lymphoma ?

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MTX + Ara-C + Thiotepa + Rituximab has superior CR compared to MTX + Ara-C with or without rituximab

lymphoma
lymphoma

what is the target of tociluzimab used for cytokine storm in CAR-T therapy ?

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IL-6R

lymphoma
lymphoma

Is there randomized prospective data to support any particular therapy for relapsed primaRY CNS lymphoma ?

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No

lymphoma
Lymphoma

Which trials have assessed the best first-line regimen for NLPHL ?

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None, no prospective randomized phase 3 trials have been performed

Lymphoma
Lymphoma

Which regimens have shown activity in anaplastic large cell lymphoma ?

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CHOP, CHOEP, APO, DA-EPOCH, BV-CHP, DHAP, GDP

Lymphoma
Lymphoma

Which major AE is of concern with the use of Denileukin Diftitox ?

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Capillary leak syndrome

Lymphoma
Lymphoma

What were the results of the MAVORIC trial ?

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PFS 7 vs 3 months in favor of mogamulizumab, p<0.01

Lymphoma
Lymphoma

What did the MAVORIC trial assess ?

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Mogamulizumab Versus Vorinostat in Previously Treated Cutaneous T-cell Lymphoma (MF/SS)

Lymphoma
Lymphoma

What were the results of the ALCANZA trial ?

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Brentuzimab is superior to physician’s choice in progressive CD30+ previously treated cutaneous anaplastic large cell lymphoma/Mycosis Fungoides

Lymphoma
Lymphoma

What did the ALCANZA trial assess ?

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Brentuximab vs physician’s choice in CD30+ previously treated cutaneous anaplastic large cell lymphoma/Mycosis Fungoides

Lymphoma
Lymphoma

What is the target of bexarotene ?

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Retinoid X receptor

Lymphoma
Lymphoma

Is there phase 3 data supporting the use of a particular regimen in NK-cell L/L (nasal type) ?

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No, variation of regimens incorporating RT with platinum agent, ifosfamide, etoposide, gemcitabine and asparaginase

Lymphoma
Lymphoma

Has a superiority of SMILE or DDGP been demonstrated in newly diagnosed advanced NK/T-cell lymphoma ?

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Yes, DDGP has shown to be superior in the Chinese CTTNKTL-III/IV trial

Lymphoma
Lymphoma

What is the DDGP regimen used in advanced NK/T-cell lymphoma ?

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Dex, cisplatin, PEG-Asparaginase

Lymphoma
Lymphoma

Which regimens are commonly used in advanced NK/T-cell lymphoma ?

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SMILE and DDGP

Lymphoma
Lymphoma

Was there an improvement in PFS with the ECHELON-2 trial ?

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Yes

Lymphoma
Lymphoma

Has an OS been demonstrated with GDPT versus CHOP ?

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Yes

Lymphoma
Lymphoma

What is the CHOP-AL regimen ?

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CHOP- Alemtuzumab

Lymphoma
Lymphoma

What was the first approval for mogamulizumab ?

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r/r Mycosis fungoides/Sezary syndrome

Lymphoma
Lymphoma

What is the target of mogamulizumab ?

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CCR4

Lymphoma
Lymphoma

Has R-CHOP-14 proven superior to R-CHOP-21 ?

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No

Lymphoma
Lymphoma

What were the results of the FLYER trial in first line DLBCL ?

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In young patients with aggressive B-cell non-Hodgkin lymphoma and favorable prognosis, four cycles of R-CHOP is non-inferior to six cycles of R-CHOP

Lymphoma
Lymphoma

What did the FLYER trial assess in DLBCL ?

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First-line CHOP x 4 or 6 cycles with 6 cycles of rituximab in young patients with newly diagnosed DLBCL and favorable prognosis

Lymphoma
Lymphoma

What were the results of the PHOENIX trial in DLBCL ?

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Ibrutinib only improved PFS and OS in those younger than 60, worsened outcomes in those over 60

Lymphoma
Lymphoma

What did the PHOENIX trial assess in DLBCL ?

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Ibrutinib added to R-CHOP in newly diagnosed non-Germinal center DLBCL

Lymphoma

Lymphoma

What were the results of the GALGB 50303 trial ?

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DA-R-EPOCH does not improve PFS or OS versus R-CHOP in newly diagnosed DLBCL

Lymphoma

What did the CALGB 50303 trial assess in DLBCL ?

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DA-R-EPOCH vs R-CHOP in first-line DLBCL

Lymphoma
Lymphoma

Which patient population derived the most benefit from R-HyperCVAD in the MDACC-2005-0054 trial ?

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Younger than 45, otherwise unacceptable mortality

Lymphoma
Lymphoma

What did the GELTAMO trial assess in DLBCL ?

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Treatment intensification after 3 cycles of R-Mega-CHOP with FDG-avid PET randomized to further R-Mega-CHOP (complete response) or R-IFE then BEAM -Auto-HSCT (persistent disease)

Lymphoma
lymphoma

Is there phase 3 data supporting the addition of lenalidomide to R-CHOP as first line treatment ?

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No, only phase 2

lymphoma
Lymphoma

What were the results of the SWOG 9704 trial for DLBCL ?

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PFS improvement in Auto-HSCT arm (especially double hit and expressor) but not OS

Lymphoma
Lymphoma

What did the SWOG 9704 trial assess for DLBCL consolidation ?

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Auto-HSCT versus observation following R-CHOP or CHOP in the first line setting of int-high and high-risk DLBCL

Lymphoma
Lymphoma

What did the HD2002 trial determine for rituximab maintenance in DLBCL after first-line treatment ?

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Improvement in OS in males only

Lymphoma
Lymphoma

What were the results of the REMARC trial in DLBCL ?

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Improvement in PFS, not-reached versus 59 months

Lymphoma
Lymphoma

What did the REMARC trial assess in DLBCL ?

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Phase 3 trial of lenalidomide maintenance following PR/CR to first-line R-CHOP in elderly patients

Lymphoma
Lymphoma

Which salvage regimen for r/r DLBCL has phase 3 data supporting superiority of any particular regimen ?

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HOVON-44 trial R-DHAP/R-VIM vs DHAP/VIM

Lymphoma
Lymphoma

What were the results of the PARMA trial ?

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Superior OS in the Auto-HSCT arm versus R-DHAP in r/r DLBCL as first line salvage

Lymphoma
lymphoma

What did the PARMA trial assess ?

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Phase 3 trial of BEAC-Auto-HSCT versus R-DHAP in r/r DLBCL as first line salvage

lymphoma
lymphoma

Which phase 3 trial supports the advantage of Allo-HSCT in r/r DLBCL ?

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None

lymphoma
Lymphoma

What were the results of the CORAL trial ?

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No advantage to adding rituximab maintenance following Auto-HSCT

Lymphoma
Lymphoma

What did the CORAL trial assess in DLBCL ?

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Efficacy of rituximab maintenance after Auto-HSCT in r/r DLBCL

Lymphoma
Lymphoma Transplant

Were patients with prior auto-HSCT allowed in the ZUMA-1 trial ?

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Yes, within 12m of transplant

Lymphoma Transplant
Lymphoma

Which myeloablative regimen is used with Axicabtagene ciloleucel ?

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Cyclophosphamide + fludarabine

Lymphoma
Lymphoma

What was the most common grade 3/4 AE in ZUMA-1 ?

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Neutropenia

Lymphoma
Lymphoma

What was the ZUMA-1 trial trying to assess in DLBCL ?

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Efficacy of Axicabtagene ciloleucel in r/r DLBCL, PMBCL, and transformed FL

Lymphoma
Lymphoma

Which phase 3 trial shows the superiority of Axicabtagene ciloleucel over Auto-HSCT for r/r DLBCL ?

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None, only phase 2 non-randomized data

Lymphoma
Lymphoma

What are the most common grade 3/4 AEs seen with polatuzumab + BR in r/r DLBCL ?

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Neutropenia, anemia, thrombocytopenia

Lymphoma
Lymphoma

Is there phase 3 data supporting the use of Ofatumumab – ICE over R-ICE for r/r DLBCL ?

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No

Lymphoma
Lymphoma

What did the ORCHARRD trial assess for DLBCL ?

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Ofatumumab – DHAP vs R-DHAP for r/r DLBCL

Lymphoma
Lymphoma

What were the results of the GOYA trial for DLBCL ?

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G-CHOP did not improve PFS vs R-CHOP

Lymphoma
Lymphoma

What was the GOYA trial for DLBCL ?

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Obinutuzumab-CHOP vs R-CHOP, phase 3 , first-line DLBCL

Lymphoma
Lymphoma

What is the G-CHOP regimen ?

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Obinutuzumab – CHOP

Lymphoma
Lymphoma

What is the V in the R-CVEP regimen for r/r DLBCL ?

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Vorinostat

Lymphoma
Lymphoma

Is there phase 3 data supporting the use of R-Gem-Ox in r/r DLBCL ?

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No, only phase 2

Lymphoma
Lymphoma

What did the JULIET trial assess in DLBCL ?

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Tisagenlecleucel in r/r DLBCL ineligible for Auto-HSCT or had progression

Lymphoma
Lymphoma

Is there phase 2 or 3 data assessing the utility of lenalidomide + rituximab in r/r DLBCL in elderly patients ?

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Yes, Phase 2

Lymphoma
Lymphoma

What is the R-DHAP regimen used in lymphoma?

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Rituximab, dexamethasone, cytarabine, platinum agent

Lymphoma
lymphoma

What is another name for the Ki-67 protein ?

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MIB-1

lymphoma
lymhpoma

What is the dosing of zanubrutinib ?

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160mg BID or 320mg QD

lymhpoma
Lymphoma

What cytogenetic changes are seen with anaplastic large cell lymphoma?

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t(2;5)

Lymphoma
Lymphoma

What antibody treatment is used for T-cell PLL?

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Alemtuzumab

Lymphoma
Lymphoma

What is the flow cytometry signature for T-cell PLL?

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TdT negative, CD1a negative, CD2 positive, CD7 positive, CD52 positive

Lymphoma
Lymphoma

What is lymphomatoid granulomatosis and how is it treated?

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Epstein-Barr virus associated lymphoma involving blood vessels, aggressive, treated with R CHOP

Lymphoma
Lymphoma

What dose of radiation can be given for nasal type natural killer cell lymphoma concurrent with
cisplatin?

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Concurrent radiotherapy with cis-platinum and a total radiation dose of 4000-5210 centigray followed
by adjuvant ICE for 3 cycles
SMILE regimen

Lymphoma
Lymphoma

What are the 2 clinical patterns of HTLV-I driven adult T cell Kenya lymphoma?

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Chronic / indolent versus aggressive

Lymphoma
Lymphoma

What are unique features of adult T cell leukemia lymphoma?

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Flower cells
bone metastases
elevated calcium

Lymphoma
Lymphoma

What is the target of Denileukin?

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CD25 by IL-2 conjugate

Lymphoma
Lymphoma

What defines stage III mycosis fungoides?

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Greater than 80% body surface area

Lymphoma
Lymphoma

What are some local therapy options for mycosis fungoides?

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Topical steroids, topical carmustine, topical retinoids, phototherapy, Imiquimod

Lymphoma
Lymphoma

What serum markers with low signature can diagnose Sezary syndrome?

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Positive clonal T-cell receptor, 1000 Sezary cells per microliter
CD4 to CD8 ratio greater than 10
Greater than 40% CD4 positive CD7 negative cells or greater than 30% CD4 positive CD26 negative cells

Lymphoma
Lymphoma

What is the primary difference between mycosis fungoides and Sezary syndrome with respect to
therapy?

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Sezary syndrome requires systemic therapy
Mycosis fungoides topical and local treatment

Lymphoma
Lymphoma

What 3 salvage regimens are available for relapse or rectory diffuse large B-cell lymphoma?

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RICE, REPOCH, RESHAP

Lymphoma
Lymphoma

What ALK status is worse for anaplastic large cell lymphoma?

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ALK positive lymphoma has better prognosis

Lymphoma
Lymphoma

How can you treat primary effusion lymphoma?

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DA-R-EPOCH

Lymphoma
Lymphoma

What are the sanctuary sites for lymphoblastic lymphoma?

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Central nervous system, testes

Lymphoma
Lymphoma

Which regimen is generally recommended for lymphoblastic lymphoma treatment?

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hyperCVAD

Lymphoma
Lymphoma

What is the difference between lymphoblastic lymphoma and T-cell ALL?

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At least 25% bone marrow involvement for T-cell ALL

Lymphoma
Lymphoma

What is a clonal marker for lymphoblastic lymphoma?

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T-cell receptor gene rearrangement

Lymphoma
Lymphoma

Which clinical presentation is common with lymphoblastic lymphoma?

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Young man with mediastinal mass

Lymphoma
Lymphoma

What is the immunohistochemistry pattern for lymphoblastic lymphoma?

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CD3 positive, CD7 positive, TDT positive

Lymphoma
Lymphoma

When can one consider allogeneic stem cell transplant for diffuse large B-cell lymphoma?

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Failure of autologous stem cell transplant, CAR-T

Lymphoma
Lymphoma

What are 2 indicators of poor autologous stem cell transplant outcomes with diffuse large B-cell
lymphoma?

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Prior rituximab use, primary refractory disease

Lymphoma
Lymphoma

What are the known risk factors for developing central nervous system involvement for diffuse large B-
cell lymphoma?

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Primary testicle, primary paranasal, HIV, bone marrow involvement, greater than 2 extranodal sites

Lymphoma
Lymphoma

What percentage of diffuse large B-cell lymphoma has central nervous system involvement?

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5-10%

Lymphoma
Lymphoma

How do you treat primary effusion lymphoma?

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First line is CHOP
Second line is CODOXM/IVAC

Lymphoma
Lymphoma

Where does plasmablastic lymphoma generally present?

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Oral cavity

Lymphoma
Lymphoma

How does primary effusion lymphoma present?

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Isolated ascites and pleural effusion

Lymphoma
Lymphoma

Which non-Hodgkin’s lymphoma in AIDS patients is associated with HHV-8 and Epstein-Barr virus?

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Primary effusion lymphoma

Lymphoma
Lymphoma

What is a very important serum marker that determines chemotherapy related death for patients with
HIV?

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CD4 count less than 50

Lymphoma
Lymphoma

What is considered salvage therapy for primary central nervous system lymphoma?

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Radiation therapy, rituximab, temozolomide, autologous stem cell transplantation

Lymphoma
Lymphoma

Which 2 chemotherapy agents are considered front-line for primary CNS lymphoma?

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Methotrexate and Ara-C

Lymphoma
Lymphoma

What are the three chemotherapy agents in theFLAG-IDA regimen?

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Fludarabine, idarubicin, Ara-C

Lymphoma
Lymphoma

What are histologic poor risk features of cutaneous T-cell lymphoma?

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P53 positive Ki-67 > 25%, CXCR3 positive, CCR4 negative, CD30 positive, CD 56 positive, BCL-2 positive,
BCLXL +

Lymphoma
Lymphoma

Which IHC marker will be seen in primary effusion lymphoma?

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CD20 negative, CD79a negative, PAX5 negative
CD30 positive, CD38 positive, CD45 positive CD138 positive

Lymphoma
Lymphoma

What are the histologic features of angioimmunoblastic lymphoma?

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Follicular helper T cells, CD10 positive, BCL6 positive, CD2 positive, CD3 positive, CD4 positive, CD5
positive, CXCL13 -positive

Lymphoma
Lymphoma

What hematologic features does angioimmunoblastic lymphoma present with ?

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High immunoglobulin, positive coomb’s for autoimmune hemolytic anemia

Lymphoma
Lymphoma

What is the immunohistochemistry pattern for peripheral T-cell lymphoma?

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CD2+, CD3+, TCR+, CD4+,low CD5, low CD7

Lymphoma
Lymphoma

What is the role of transplantation for peripheral T-cell lymphoma?

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Controversial

Lymphoma
Lymphoma

Which chemotherapy is preferred for peripheral T-cell lymphoma not otherwise specified?

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CHOEP

Lymphoma
Lymphoma

Which chromosome location is the cMYC oncogene located on ?

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8q24

Lymphoma
Lymphoma

Which lymphoma does Chlamydia Pistacci cause?

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Orbital adnexal lymphoma

Lymphoma
Lymphoma

What lymphoma does human herpesvirus 8 cause?

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Castleman, body cavity lymphoma

Lymphoma
Lymphoma

Which infectious agents cause non-Hodgkin lymphoma?

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Epstein-Barr virus, human herpesvirus 8, hepatitis C, HTLV-1, H. pylori, HTLV-1, C jejuni, C Pistacci,
Borrelia

Lymphoma
Lymphoma

If an excisional biopsy is not possible, what type of biopsy is acceptable to properly diagnosed
lymphoma?

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Core biopsy

Lymphoma
Lymphoma

What is the difference in clinical presentation between a reactive lymph node versus a malignant lymph node?

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Reactive lymph nodes are painful
Malignant lymph nodes are painless

Lymphoma
Lymphoma

What is the preferred treatment for stage I and stage II diffuse large B-cell lymphoma?

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3 cycles of R–CHOP plus localized radiotherapy

Lymphoma
Lymphoma

What constitutes the FLIPI score ?

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LDH, hemoglobin, beta-2 microglobulin, the number of extranodal sites

Lymphoma
Lymphoma

What did the GELA clinical trial show for diffuse large B-cell lymphoma?

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Addition of rituximab improves overall survival

Lymphoma
Lymphoma

What 2 risk factors are known to cause non-Hodgkin’s lymphoma?

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Pesticide and AIDS

Lymphoma
Lymphoma

How you consolidate angioimmunoblastic T-cell lymphoma?

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Autologous stem cell transplant

Lymphoma
Lymphoma

What are some examples of indolent T-cell lymphomas?

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Mycosis fungoides, primary cutaneous anaplastic lymphoma

Lymphoma
Lymphoma

What is the target of tisagenlecleucel?

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CD-19

Lymphoma
Lymphoma

What is the long-term overall survival advantage to an allogeneic stem cell transplant and autologous
stem cell transplant for relapsed / refractory non-Hodgkin’s lymphoma?

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No difference

Lymphoma
Lymphoma

Which radiopharmaceutical is available in the United States for relapsed / refractory non-Hodgkin’s
lymphoma?

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Yttrium-90 – Ibritumomab

Lymphoma
Lymphoma

What level of bone marrow biopsy involvement and complete blood count requirements are needed prior to radio-
immunotherapy use in relapsed / refractory lymphoma ?

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Platelet count greater than 100,000 and less than 25% bone marrow involvement

Lymphoma
Lymphoma

What is the flow signature for CLL?

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CD5 positive, CD19 positive, CD23 positive, CD20 positive (dim), low surface immunoglobulin staining

Lymphoma
Lymphoma

Which genes are fused in a t(11;18) translocation?

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APLI2/MCT – prevents apoptosis

Lymphoma
Lymphoma

What is the first-line treatment for mycosis fungoides?

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Superficial skin treatment, radiotherapy, ultraviolet A, steroid creams

Lymphoma
Lymphoma

What is the difference between Sezary syndrome and mycosis fungoides?

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Positive peripheral blood and erythroderma – Sezary syndrome

Lymphoma
Lymphoma

What confers a good versus poor prognosis in cutaneous T-cell lymphoma?

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Alpha-beta T-cell receptor gene rearrangement is good prognosis
Gamma delta T-cell receptor gene rearrangement is poor prognosis

Lymphoma
Lymphoma

Which lymphoma can involve the pannus?

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Panniculitis-like T-cell lymphoma

Lymphoma
Lymphoma

Which demographic is gamma delta hepatosplenic T-cell lymphoma seen in?

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Young males

Lymphoma
Lymphoma

Which cytogenetic signature is seen with hepatosplenic gamma delta lymphoma?

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Isochrome 7q

Lymphoma
Lymphoma

Which treatment works for enteropathy associated T-cell lymphoma?

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CHOP or ifosfamide–etoposide, epirubicin, methotrexate plus autologous stem cell transplant

Lymphoma
Lymphoma

Which lymphomas are associated with celiac disease?

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Enteropathy associated T-cell lymphoma

Lymphoma
Lymphoma

What is the treatment for anaplastic large cell lymphoma?

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CHOP

Lymphoma
Lymphoma

Which translocation is seen in ALK mutated anaplastic large cell lymphoma?

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t(2;5)

Lymphoma
Lymphoma

What defines anaplastic large cell lymphoma?

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CD30 positive T-cell lymphoma, CD2 positive, CD4 positive, CD5 positive, CD3 negative

Lymphoma
Lymphoma

Which immunohistochemistry pattern is seen with diffuse large B-cell lymphoma?

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CD5 negative, CD19 positive, CD20 positive, CD23 negative, CD10 positive/negative depending on
activated B-cell versus germinal center

Lymphoma
Lymphoma

In the PRIMA study, what is the 3 year progression-free survival?

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75% versus 57% for those with maintenance rituximab?

Lymphoma
Lymphoma

What are the FLIPI-2 variables?

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Age, hemoglobin, diameter of the lymph node, beta-2 microglobulin, bone marrow involvement

Lymphoma
Lymphoma

Which CD10 positive lymphoma has a BCL-2 positive stain?

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Follicular

Lymphoma
Lymphoma

Which chromosome is the heavy chain immunoglobulin gene on?

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Chromosome 14

Lymphoma
Lymphoma

Which cytotoxic chemotherapy regimen is good for mycosis fungoides, Sezary syndrome when they fail
local therapy?

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None, targeted therapies much better than chemotherapy

Lymphoma
Lymphoma

What is another name for Castleman syndrome?

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Multicentric angiofollicular hyperplasia

Lymphoma
Lymphoma

What type of lymphoma is a breast-implant associated lymphoma?

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Anaplastic large cell lymphoma

Lymphoma
Lymphoma

Which cytogenetic abnormality is seen with T-cell PLL?

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Inv (14)(q11q32)

Lymphoma
Lymphoma

What stains are positive in Rosai Dorfan disease?

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S100 and CD68

Lymphoma
Lymphoma

What is Rosai Dorfan disease?

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Histiocytic lymphoma with elevated immunoglobulin levels

Lymphoma
Lymphoma

Which important cluster of differentiation marker is negative in primary effusion lymphoma?

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CD20 therefore no rituximab option

Lymphoma
Lymphoma

What is the disadvantage of using bendamustine plus rituximab in diffuse large B-cell lymphoma?

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Improved overall response rate to 90%, but decreased duration of response

Lymphoma
Lymphoma

What are some risk factors for the development of central nervous system involvement of diffuse large
B-cell lymphoma?

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Paranasal primary, testicular primary, HIV, epidural involvement

Lymphoma
Lymphoma

At how many years post chemotherapy for diffuse large B-cell lymphoma is the risk of relapse lowered?

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2 years

Lymphoma
Lymphoma

How can you treat early stage diffuse large B-cell lymphoma of the testicle?

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R – CHOP for 6 cycles, testicular radiation, orchiectomy, intrathecal chemotherapy

Lymphoma
Lymphoma

Is there a survival advantage for stage II-IV diffuse large B-cell lymphoma with DA-R-EPOCH vs R-CHOP ?

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No difference in 2 year PFS or OS.

Lymphoma
Lymphoma

What are peripheral lymphoid tissue examples?

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Spleen, mucosal, blood, skin

Lymphoma
Lymphoma

What are the common T-cell surface markers?

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CD3, 4, 8, 5, T-cell gene receptor and CD3 coexpression

Lymphoma
Lymphoma

What is the equivalent of T-cell antibody maturation versus B CELL?

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B-cell is the VDJ with kappa/Lambda
T cell is alpha / beta or gamma / delta

Lymphoma
Lymphoma

Which surface immunoglobulins are present on B-cells?

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IgM and IgD

Lymphoma
Lymphoma

What cell surface marker is present on T cells?

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TdT

Lymphoma
Lymphoma

What do high antigen affinity pre-B cells turn into?

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Memory B cells in plasma cells

Lymphoma
Lymphoma

Which cell surface markers disappear when CD20 appears during B-cell development?

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CD10/TdT

Lymphoma
Lymphoma

Which stage of B- cell development is antigen dependent?

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Late stage

Lymphoma
Lymphoma

Which lymphoma does idelalisib have the highest activity in?

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Follicular lymphoma as well as CLL

Lymphoma
Lymphoma

Which 2 lymphomas are most common in HIV patients?

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Plasmablastic lymphoma and primary effusion lymphoma

Lymphoma
Lymphoma

What is the international prognostic index score for diffuse large B-cell lymphoma comprised of?

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Age older than 60, elevated lactate dehydrogenase, stage III or 4 disease, more than 2 extranodal sites,
poor performance status

Lymphoma
Lymphoma Part 2

Lymphoma Part 2

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Lymphoma Part 2

Lymphoma Part 2
Lymphoma

What is the role of radiotherapy for relapsed refractory mantle cell lymphoma?

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Palliation

Lymphoma
Lymphoma

What accounts for superior 5-year survival in patients with relapsed/refractory mantle cell lymphoma who undergo allogeneic stem cell transplant?

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Performing transplant in the first partial or complete remission

Lymphoma
Lymphoma

What type of allogeneic stem cell transplant is generally performed for patients with relapsed or refractory mantle cell lymphoma?

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Nonmyeloablative

Lymphoma
Lymphoma

When is the best time to perform an autologous stem cell transplant for patients with advanced mantle cell lymphoma?

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In first remission

Lymphoma
Lymphoma

Do patients with mantle cell lymphoma will require 2 lines of therapy to enter remission have inferior results after autologous stem cell transplant?

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No

Lymphoma
Lymphoma

Does the use of second line therapy or only a partial response to therapy predict for inferior long-term outcomes with autologous stem cell transplant for refractory mantle cell lymphoma?

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Partial remission

Lymphoma
Lymphoma

What objective response rate can be expected with venetoclax in r/r MCL ?

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75%

Lymphoma
Lymphoma

What is the expected overall response rate of idelalisib for R/R MCL?

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40%

Lymphoma
Lymphoma

What is the most challenging features of utilizing obinutuzumab and R/R MCL?

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Infusion reactions which can be seen in 75%

Lymphoma
Lymphoma

Is there data supporting the use of Ibritumomab Tiuxetan in R/R MCL?

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Yes

Lymphoma
Lymphoma

What is the most common adverse events seen with thalidomide plus rituximab in patients with R/R MCL?

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Thromboembolic events

Lymphoma
Lymphoma

What is the most common grade 3/4 adverse events seen in patients with R/R MCL treated with R-HyperCVAD?

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Neutropenic fever

Lymphoma
Lymphoma

What is the overall response rate of Brexucabtagene autoleucel in R/R MCL?

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93%

Lymphoma
Lymphoma

How common are cytopenias in patients with R/R MCL treated with Brexucabtagene autoleucel ?

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Nearly 95%

Lymphoma
Lymphoma

How common are neurologic adverse events in patients treated with Brexucabtagene autoleucel for R/R MCL?

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30%

Lymphoma
Lymphoma

Which infectious organisms are described in the black box warning for brexucabtagene autoleucel ?

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Candida/HHV-6/JC virus/aspergillus

Lymphoma
Lymphoma

What are the most challenging side effects to management utilizing tensirolimus for R/R MCL ?

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Cytopenias and asthenia

Lymphoma
Lymphoma

Which fludarabine combination has significant activity in R/R MCL ?

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R–FCM–rituximab plus fludarabine plus cyclophosphamide plus mitoxantrone

Lymphoma
Lymphoma

What is the complete response rate with single agent cladribine for R/R MCL ?

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Approximately 20%

Lymphoma
Lymphoma

Is there phase 3 data supporting the use of bendamustine plus rituximab in R/R MCL?

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Yes compared against fludarabine plus rituximab with superior PFS and OS

Lymphoma
Lymphoma

The addition of which therapeutic agent to bortezomib significantly worsens toxicity in patients with R/R MCL ?

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Rituximab

Lymphoma
Lymphoma

Which adverse events are common in patients treated with a combination of bortezomib and rituximab-containing regimen for R/R MCL ?

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Neurologic events/fatigue/thrombocytopenia

Lymphoma
Lymphoma

What are the most common adverse events with lenalidomide in R/R MCL ?

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Neutropenia and thrombocytopenia

Lymphoma
Lymphoma

Is zanubrutinib a reversible or irreversible BTK inhibitor ?

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Irreversible

Lymphoma
Lymphoma

What is the dosing and frequency of zanubrutinib for MCL ?

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160 mg twice a day

Lymphoma
Lymphoma

What is the complete response rate with zanubrutinib and R/R MCL ?

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59%

Lymphoma
Lymphoma

What is the dosing of acalabrutinib for R/R MCL ?

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100 mg twice daily

Lymphoma
Lymphoma

What is the complete response rate with a acalabrutinib with R/R MCL ?

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40%

Lymphoma
Lymphoma

What is the most common adverse event seen with acalabrutinib ?

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Headache seen in approximately 40%

Lymphoma
Lymphoma

How common is diarrhea with a acalabrutinib ?

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31%

Lymphoma
Lymphoma

Is there phase 3 data supporting the use of ibrutinib for R/R MCL?

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Yes

Lymphoma
Lymphoma

What has ibrutinib been combined with for improvements in efficacy in R/R MCL?

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Rituximab and venetoclax

Lymphoma
Lymphoma

What is a complete response with ibrutinib plus venetoclax in R/R MCL?

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42%

Lymphoma
Lymphoma

What is the approximate complete response rate with single agent ibrutinib for R/R MCL?

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23%

Lymphoma
Lymphoma Part 2

Lymphoma Part 2

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Lymphoma Part 2

Lymphoma Part 2
Lymphoma

Does VR-CAP have phase 3 data in newly diagnosed MCL ?

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Yes, showed improvement in OS versus RCHOP

Lymphoma
Lymphoma

What is the VR-CAP regimen used in the MCL ?

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Bortezomib-Rituxan-Cyclophosphamide-doxorubicin-Prednisone

Lymphoma
Lymphoma

What did the SWOG S1106 trial determine when comparing R-HyperCVAD-R-MA vs BR in newly diagnosed MCL ?

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5-yr analysis showed similar efficacy but higher toxicity with Hyper-CVAD /R-MA

Lymphoma
Lymphoma

What did the MCLYounger trial assess in newly diagnosed MCL ?

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alternating RCHOP/RDHAP vs RCHOP with planned autologous – HSCT for pts < 65yo results in superior TTTF

Lymphoma
Lymphoma

What did the MCLYounger trial assess in newly diagnosed MCL ?

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RCHOP vs alternating RCHOP/RDHAP prior to planned autologous – HSCT for pts < 65yo

Lymphoma
Lymphoma

Which regimens has RCHOP shown superiority to in newly diagnosed MCL ?

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FCR and CHOP

Lymphoma
Lymphoma

Which phase 3 trials showed the BR has superior PFS versus RCHOP in newly diagnosed MCL ?

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StiL NHL-1 and BRIGHT

Lymphoma
Lymphoma

Is there randomized phase 3 data to support the use of R-MACLOR/R-IVAM in newly diagnosed MCL ?

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No, only phase 2 data

Lymphoma
Lymphoma

Is there randomized phase 3 data to support the use of R-M-CHOP in newly diagnosed MCL ?

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No, only phase 2 data

Lymphoma
Lymphoma

Is there randomized phase 3 data to support the use of R-DHAP or R-DHAC in newly diagnosed MCL ?

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No, only phase 2 data

Lymphoma
Lymphoma

Has a Phase 3 trial shown an improvement in PFS with early Auto-HSCT consolidation in MCL ?

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Yes, Dreyling et al, compared to IFN-alpha

Lymphoma
Lymphoma

What were the results of the MCLelderly trial in first-line MCL ?

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RCHOP with rituximab maintenance is superior to RCHOP + observation as well as the FCR cohorts wrt OS

Lymphoma
Lymphoma

What was the purpose of the MCLelderly trial in first-line MCL ?

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FCR vs RCHOP followed by maintenance rituximab or observation in patients older than 60 as first line treatment

Lymphoma
Lymphoma

What were the outcomes of the LyMa trial in MCL ?

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maintenance rituximab improves EFS, PFS and OS after transplantation in MCL

Lymphoma
Lymphoma

What was the purpose of the LyMa trial in MCL ?

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maintenance rituximab following Autologous stem cell transplant in MCL

Lymphoma
Lymphoma

What were the results of the NCRN-Ply-26 trial in r/r MCL ?

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Bortezomib-CHOP shows superior OS and ORR compared to CHOP in r/r MCL

Lymphoma
Lymphoma 123412341234

What was the purpose of the NCRN-Ply-26 trial in r/r MCL ?

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Compare Bortezomib-CHOP to CHOP in r/r MCL

Lymphoma 123412341234
Lymphoma

What were the results of the StiL -NHL- 2-2003 trial in r/r MCL ?

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BR has superior OS to FR

Lymphoma
Lymphoma

What was the purpose of the StiL -NHL- 2-2003 trial in r/r MCL ?

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BR vs FR in r/r MCL

Lymphoma
Lymphoma

What was the result of the SPRINT trial in r/r MCL ?

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Lenalidomide has superior PFS versus investigator’s choice of cytarabine rituximab, gemcitabine, fludarabine, chlorambucil in pts not eligible for aggressive treatment with r/r MCL

Lymphoma
Lymphoma

What was the purpose of the SPRINT trial in r/r MCL ?

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Lenalidomide vs investigator’s choice of cytarabine rituximab, gemcitabine, fludarabine, chlorambucil in pts not eligible for aggressive treatment in r/r MCL

Lymphoma
Lymphoma

What was the purpose of the RAY trial in r/r MCL ?

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Ibrutinib vs tenserolimus in r/r MCL

Lymphoma
Lymphoma

What was the most common AE reported in the ACE-LY-004 trial for r/r MCL with acalabrutinib ?

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Headache

Lymphoma
Lymphoma

What did the ACE-LY-004 trial assess in MCL ?

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Acalabrutinib in r/r MCL

Lymphoma
Lymphoma

Is there randomized data to support the use of maintenance rituximab after salvage in MCL ?

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Yes, after salvage R-FCM, Forspointer et al.

Lymphoma
Lymphoma

What comprises the PEP-C regimen for r/r mantle cell lymphoma?

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Prednisone, etoposide, procarbazine, cyclophosphamide

Lymphoma
Lymphoma

What are some non-chemotherapy options for early recurrent mantle cell lymphoma?

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Lenalidomide, rituximab,ibrutinib, acalbrutinib, zanubrutinib , venetoclax

Lymphoma
Lymphoma

Is there randomized data to support the use of maintenance ofatumumab instead of rituximab for mantle cell lymphoma?

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No

Lymphoma
Lymphoma

What consolidation can be offered instead of Auto-HSCT for mantle cell lymphoma following induction chemotherapy ?

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Maintenance rituximab

Lymphoma
Lymphoma

For patients that receive consolidative autologous stem cell transplant after going into remission with induction chemotherapy for mantle cell lymphoma, what can predict for a 100% 5-year overall survival?

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Low serum beta 2 microglobulin

Lymphoma
Lymphoma

If there data to support the use of alternating RCHOP and RDHAP in mantle cell lymphoma?

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Yes, improvements in overall response rate, median time to treatment failure, complete remission rates all statistically significant except for a 5-year overall survival, only a trend from the European MCL network

Lymphoma
Lymphoma

What are some non-chemotherapy options for stage I and non-bulky stage II mantle cell lymphoma?

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Involved site radiotherapy or observation in very select cases

Lymphoma
Lymphoma

Does the national cancer center network recommend upper endoscopy and colonoscopy as part of the initial workup for newly diagnosed mantle cell lymphoma?

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Only in highly suspicious cases involving the gastrointestinal tract

Lymphoma
Lymphoma

What percentage of mantle cell lymphoma cases involve the gastrointestinal tract?

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15-30%

Lymphoma
Lymphoma

What would warrant lumbar puncture with a new diagnosis of mantle cell lymphoma?

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Blastic variant and the presence of central nervous system –related symptoms or signs

Lymphoma
Lymphoma

What prognosis does TP53 mutation confer in mantle cell lymphoma?

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Poor

Lymphoma
Lymphoma

What Ki-67 threshold is generally associated with a better prognosis for mantle cell lymphoma?

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30%

Lymphoma
Lymphoma

Which genetic rearrangement can be seen in CyclinD1 negative mantle cell lymphoma?

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CCND2 gene

Lymphoma
Lymphoma

What percentage of mantle cell lymphoma have positive staining for cyclin D1 ?

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95%

Lymphoma
Lymphoma

Which protein is overexpressed with the chromosomal translocation of mantle cell lymphoma ?

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CyclinD1

Lymphoma
Lymphoma

Which genes are juxtaposed with the t(11;14) translocation in mantle cell lymphoma?

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cyclinD1 locus and IGH locus

Lymphoma
Lymphoma

Which chromosomal translocation is seen in mantle cell lymphoma?

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t(11;14)

Lymphoma
Lymphoma

What percentage of newly diagnosed lymphomas are mantle cell lymphoma?

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3-4%

Lymphoma
Lymphoma

Which anatomic regions have a low FDG avidity in mantle cell lymphoma?

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Gastrointestinal tract and bone marrow

Lymphoma
lymhpoma

What is the starting dose of acalbrutinib for mantle cell lymphoma ?

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100mg BID

lymhpoma
lymhpoma

What was the first indication for zanubrutinib ?

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r/r mantle cell lymphoma following a single line of therapy

lymhpoma
Lymphoma

Which 2 cell surface markers can distinguish mantle cell lymphoma from
CLL?

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CD23+ and FMC7- in CLL and the reverse in MCL

Lymphoma
Lymphoma

Where is a unique and common anatomic region that mantle cell lymphoma can present in?

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GI mucosal tract

Lymphoma
Lymphoma

Which translocation is seen with mantle cell lymphoma?

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t(11;14)

Lymphoma
Lymphoma

What is the cell surface marker profile for mantle cell lymphoma?

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CD20 and CD5 positive, CD10 and CD23 negative

Lymphoma
Lymphoma

How can you distinguish between mantle cell blastoid variant versus Burkitt’s?

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MCL Cd10- CD5+
BL opposite

Lymphoma
Lymphoma

Which three other types of lymphoma should be on the differential diagnosis of Burkitt’s?

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ALL, mantle cell blastoid type, diffuse large B cell

Lymphoma
Lymphoma

Which 5 lymphomas comprise 85% of all cases?

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Follicular, large cell, chronic lymphocytic leukemia, MALT lymphoma, mantle cell lymphoma

Lymphoma
Lymphoma

What consolidation therapy is recommended after primary induction for mantle cell lymphoma if patients are not autologous
stem cell transplant candidates?

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Rituximab

Lymphoma
Lymphoma

What is the dose of inrutinib administerd for mantle cell lymphoma?

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560 mg per day

Lymphoma
Lymphoma

Which study compared bendamustine rituximab to R-CHOP for indolent lymphoma and mantle cell
lymphoma?

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StiL study

Lymphoma
Lymphoma

Which lymphomas occur in the pre-germinal center?

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Mantle cell lymphoma

Lymphoma
Lymphoma

Is there randomized phase 3 data supporting the use of R-Hyper-CVAD/R-MA versus another regimen for Burkitt lymphoma ?

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No

Lymphoma
Lymphoma

Which cytogenetic changes can be seen with Burkitt lymphoma?

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t(8;14), t(2;8), t(8;22)

Lymphoma
Lymphoma

What is a distinguishing diagnostic feature of Burkitt’s lymphoma?

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cMYC 100%, Ki-67 of 99-100%

Lymphoma
Lymphoma

What causes that “starry sky” appearance for Burkitt lymphoma?

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Macrophage phagocytosis of tumor cells

Lymphoma
Lymphoma

Which lymphomas are HIV patients at greater risk of developing ?

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High grade lymphoma, Burkitt with plasmacytoid differentiation, diffuse large B-cell lymphoma, atypical
Berkitt’s, primary effusion lymphoma, body cavity lymphoma, plasma blastic lymphoma, primary central
nervous system non-Hodgkin’s lymphoma

Lymphoma
Lymphoma

What is a very well-established risk factor for Burkitt lymphoma?

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AIDS

Lymphoma
Lymphoma

Howe do the cells on histology defer between Burkitt and diffuse large B-cell lymphoma ?

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Burkitt’s has medium-sized cells, diffuse large B-cell has large cells

Lymphoma
Lymphoma

What are other names given for lymphoma with features between Burkitt and diffuse large B-cell?

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Atypical Burkitt lymphoma, high grade lymphoma, Burkitt-like lymphoma

Lymphoma
Lymphoma

Name 3 aggressive chemotherapy regimens for Burkitt lymphoma?

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DA-R-EPOCH, R-HyperCVAD, R-CODOXM/IVAC

Lymphoma
Lymphoma

What is the difference between African (endemic) Burkitt and non-African Burkitt lymphoma?

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Endemic version in Africa 100% driven by Epstein-Barr virus: Generally seen in the jaw

Lymphoma
Lymphoma

What is a typical Ki-67 percentage for Burkitt’s lymphoma ?

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99-100%

Lymphoma
Lymphoma

Which two genes are translocated in Burkitt’s ?

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C-Myc
Ig heavy chain

Lymphoma
Lymphoma

Which cell surface markers do Burkitt cells express ?

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CD10,19,20,22,79a

Lymphoma
Lymphoma

Which cell surface markers do Burkitt’s cells lack?

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CD5 CD23 TdT BCL2

Lymphoma
Lymphoma

What are three important features of Burkitt’s lymphoma on histology?

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Small cell size, large nucleus, numerous

Lymphoma
Lymphoma

How do endemic and sporadic versions of Burkitt’s differ ?

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Sporadic abdominal and visceral symptoms
Endemic – face / jaw

Lymphoma
Lymphoma

What are the chemotherapy agents in hyperCVAD for Burkitt’s lymphoma?

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View Question

methotrexate, prednisone, cyclophosphamide, Ara-C, vincristine, prednisone

Lymphoma
Lymphoma

What are the three major subcategories of Burkitt’s lymphoma?

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View Question

Endemic, sporadic, immunodeficiency related

Lymphoma
Lymphoma

What percentage of lymphoma in adults vs children is Burkitt’s?

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View Question

1% adults
30% pediatric

Lymphoma
Lymphoma

Which labs should always be checked for a new diagnosis of Burkitt’s lymphoma?

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View Question

HIV, LDH, hepatitis B, lumbar puncture with flow cytometry

Lymphoma
Lymphoma

What are the four major treatment options for Burkitt’s lymphoma?

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View Question

HyperCVAD
CODOX-M
CALGB 9251
DA-EPOCH
All with or without rituximab

Lymphoma
Lymphoma

Which chemotherapy agents are part of the CALGB 9251 Regimen for Burkitt’s lymphoma?

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Ifosfamide, methotrexate, vincristine, dexamethasone, Ara-C, anthracycline

Lymphoma
Lymphoma

What is the leukemia variant of Burkitt’s lymphoma?

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View Question

ALL-L3

Lymphoma
Lymphoma

Which Burkitt’s subtype has the most central nervous system and bone marrow involvement?

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View Question

Immunodeficiency > sporadic > endemic

Lymphoma
Lymphoma

What is the median age for sporadic Burkitt’s lymphoma?

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View Question

30 years old

Lymphoma
Lymphoma

What are two other lymphomas that are world health organization categorized in a similar fashion as Burkitt’s
lymphoma?

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View Question

Burkitt-like
B-cell lymphoma NOS

Lymphoma
Lymphoma

How can you distinguish between mantle cell blastoid variant versus Burkitt’s?

View Answer
View Question

MCL Cd10- CD5+
BL opposite

Lymphoma
Lymphoma

Which three other types of lymphoma should be on the differential diagnosis of Burkitt’s?

View Answer
View Question

ALL, mantle cell blastoid type, diffuse large B cell

Lymphoma
Lymphoma

Which three chromosome translocations are possible in Burkitt’s lymphoma?

View Answer
View Question

t(8;14)
t(2;8)
t(8;22)

Lymphoma
Lymphoma

Which lymphoma does Epstein-Barr virus cause?

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View Question

Hodgkin’s, Burkitt’s, post-transplant lymphoproliferative disorder

Lymphoma
Lymphoma

What is the difference in maintenance therapy for Burkitt lymphoma versus indolent lymphoma?

View Answer
View Question

No maintenance for Burkitt lymphoma

Lymphoma
Lymphoma

What did the ECHELON-2 trial assess in PTCL ?

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View Question

Phase 3 randomized trial of Brentuximab in CD30+ plus CHOP versus CHOP in newly diagnosed PTCL

Lymphoma
Lymphoma

Is there phase 3 randomized data to support the use of CHOEP-14 in newly diagnosed PTCL ?

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View Question

No, only phase 2 data

Lymphoma
Lymphoma

What is the T in the GDPT trial for PTCL ?

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View Question

Thalidomide

Lymphoma
Lymphoma

Which regimens have shown superiority to CHOP in newly diagnosed PTCL ?

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View Question

BV-CHP , CMED, GDPT

Lymphoma
Lymphoma

What was the PTCL – 06 trial assessing in PTCL ?

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View Question

Induction CHOP-AL in newly diagnosed PTCL who were then randomized to Allo-HSCT, Auto-HSCT or further cycles of CHOP-AL

Lymphoma
Lymphoma

What is DD-CHOP in PTCL ?

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View Question

Denilukin Diftitox – CHOP

Lymphoma
Lymphoma

What did the CONCEPT trial assess in PTCL in PTCL ?

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View Question

First line DD-CHOP in newly diagnosed PTCL

Lymphoma
Lymphoma

What was the most common grade 3/4 AE seen with pralatrexate in the PROPEL trial in PTCL ?

View Answer
View Question

Thrombocytopenia, 30%

Lymphoma
Lymphoma

What did the PROPEL trial assess in PTCL ?

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View Question

Pralatrexate in second or later line PTCL

Lymphoma
Lymphoma

What was the most common grade 3/4 AE seen with belinostat in the BELIEF trial in PTCL ?

View Answer
View Question

Anemia, 10%

Lymphoma
Lymphoma

What did the BELIEF trial assess in PTCL ?

View Answer
View Question

Belinostat in second or later line PTCL

Lymphoma
Lymphoma

What did the BENTLY trial assess in PTCL ?

View Answer
View Question

Bendamustine in second or later line PTCL (all subtypes)

Lymphoma
Lymphoma

Is there activity with brentuzimab vedotin in PTCL NOS ?

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View Question

Yes

Lymphoma
Lymphoma

Which IMiD has shown activity in r/r PTCL NOS ?

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Lenalidomide, EXPECT trial

Lymphoma
Lymphoma

Is there randomized data to support the use of mogamulizumab in the second line setting for PTCL ?

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No

Lymphoma
Lymphoma

Which targeted agents are now proved for relapsed refractory PTCL ?

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Pralatrexate and romdopsin

Lymphoma
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