GIST and Sacroma

GIST and Sacroma

GIST

Which TKI has randomized second – line data in GIST refractory to imatininb ?

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Sunitinib

GIST
GIST

Has an OS been demonstrated in the use of imatinib for 3 years rather than 1 year in the adjuvant setting ?

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Yes

GIST
GIST

Is there phase 3 data to support he use of sunitinib in imatinib – refractory GIST ?

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Yes

GIST
GIST

What did the RIGHT trial assess in GIST ?

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Re-challenge with imatinib after progression on imatinib followed by another TKI shows statistically significant improvement in PFS

GIST
GIST

Which patients should not receive nilotinib with advanced GIST ?

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cKIT Exon 9 , HR vs imatinib shown to be >30 in ENESTg1 trial

GIST
GIST

Which patient subsets have inferior responses to imatinib in GIST ?

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cKIT Exon 9

GIST
GIST

What did the ENESTg1 trial assess ?

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Imatinib versus nilotinib as first line treatment in advanced GIST with imatinib being superior

GIST
GIST

What did the PASOGIST trial assess in in GIST ?

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Pazopanib after progression on imatinib in GIST

GIST
GIST

What did the GRID trial assess in GIST ?

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Regorafenib after progression on imatinib

GIST
GIST

Is there a survival advantage with sunitinib following progression on imatinib for advanced GIST ?

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Yes

GIST
Sarcoma

Does ivosidenib show activity in IDH1 mutated chondrosarcoma ?

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No

Sarcoma
GIST and Sarcoma

What is the most common side effect with imatinib use in GIST ?

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Fatigue

GIST and Sarcoma
GIST and Sarcoma

Which biopsy modality should be avoided in GIST when establishing a diagnosis ?

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Percutaneous given the risk of tumor spread as this is a soft tumor, EUS with FNA is preferred

GIST and Sarcoma
GIST and Sarcoma

What is the recommended duration of adjuvant imatinib use in resected non-metastatic high-risk GIST ?

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To be determined, but at least 3 years

GIST and Sarcoma
GIST and Sarcoma

Which TKI can be used in adjuvant setting for intermediate risk GIST patients who cannot tolerated imatinib ?

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Sunitinib

GIST and Sarcoma
GIST and Sarcoma

Can imatinib be used for neo-adjuvant reduction of GIST?

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Yes

GIST and Sarcoma
GIST and Sarcoma

When would you consider percutaneous biopsy of a GIST rather than EUS-FNA?

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Metastatic disease

GIST and Sarcoma
GIST and Sarcoma

How can you approach an unresectable GIST ?

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Neoadjuvant treatment then reimaging

GIST and Sarcoma
GIST and Sarcoma

What is the metastatic potential of a gastric GIST that is smaller than 2cm and has <5 mitoses/50 hpf?

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0% this is the lower strata

GIST and Sarcoma
GIST and Sarcoma

Which demographic is rhabdomyosarcoma most common in ?

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Children

GIST and Sarcoma
GIST and Sarcoma

Is there any value in increasing the dose of imatinib in patients that have progressive disease on imatinib 400mg with GIST?

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Yes, can go up to 800mg per day as tolerated

GIST and Sarcoma
GIST and Sarcoma

Which mutation can be checked for in GIST after progression of therapy on imatinib ?

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D842V

GIST and Sarcoma
GIST and Sarcoma

Where is the most common location for a rhabdomyosarcoma?

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Extremity

GIST and Sarcoma
GIST and Sarcoma

What is the first line treatment of desmoid tumors?

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Surgery

GIST and Sarcoma
GIST and Sarcoma

Which antiestrogen agent can be used in desmoid tumors?

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Tamoxifen

GIST and Sarcoma
GIST and Sarcoma

Which anti-inflammatory agent can be used in desmoid tumors?

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Sulindac

GIST and Sarcoma
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