Multiple myeloma

What are the diagnostic criteria for POEMS ?

2 major including polyneuropathy, demyelinating neuropathy, M-spike

Plus 1/3 major: Castleman syndrome, sclerotic bone, high levels of soluble VEGF

Plus 1/6 minor: organomegaly, volume overload, endocrinopathy, skin changes, papilledema, elevated
platelets, elevated hemoglobin

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