Hodgkin’s disease

What is the difference between the prognostic factors for stage I and 2 versus stage III and IV
forHodgkin’s lymphoma?

Stage I and 2–age greater than 40, ESR greater than 50, at least 3 sites involved, mixed cellularity,
lymphocyte depleted, presence of constitutional symptoms, bulky disease
Stage III and 4–male gender, age greater than 45, albumin less than 4, hemoglobin less than 10.5, white
blood cell count greater than 15, absolute lymphocyte count less than 800