Esophageal cancer

Esophageal cancer

Esophageal Cancer

 

Is squamous cell carcinoma seen in younger or older patients versus adenocarcinoma? 

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Younger

Esophageal Cancer
Esophageal Cancer

Which subtype of esophageal cancer associated with GERD?

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 Adenocarcinoma

Esophageal Cancer
Esophageal Cancer

Is the incidence of squamous cell carcinoma of the esophagus increasing or decreasing in the United States? 

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Decreasing

Esophageal Cancer
Esophageal Cancer

Should squamous histology prompted different approach for neoadjuvant treatment for esophageal cancer? 

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No

Esophageal Cancer
Esophageal Cancer

 

What defines N2 for esophageal cancer? 

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 3-6 involved regional lymph nodes

Esophageal Cancer
Esophageal Cancer

 

What defines T4 for esophageal cancer? 

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Invasion of adjacent structures including pleura diaphragm azygos vein peritoneum aorta vertebral body or airway

Esophageal Cancer
Esophageal Cancer

What is the difference between T2 and T3 esophageal cancer? 

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T2 invades muscularis propria while T3 invades adventitia

Esophageal Cancer
Esophageal Cancer

How many new cases of esophageal cancer diagnosed in the US every year? 

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19000

 

Esophageal Cancer
Esophageal Cancer

Which trial showed the efficacy of ramucirumab in advanced gastric and GEJ cancer ?

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REGARD, phase III after progression on 5-FU or Plt-based chemo

Esophageal Cancer
Esophageal cancer

What did the RAINBOW trial assess in advanced gastric/GEJ cancer ?

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Ramucirumab plus paclitaxel after progression on first-line chemo

Esophageal cancer
Esophageal cancer

How can Barrett’s esophagus with high-grade dysplasia be reported on the pathology report?

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Tis or high-grade dysplasia

Esophageal cancer
Esophageal cancer

What does Barrett’s esophagus NOT predispose patients to?

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Squamous cell carcinoma

Esophageal cancer
Esophageal cancer

What tissues differentiate T4a vs T4b esophageal cancer?

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T4a pericardium pleural diaphragm
T4b great vessels, aorta, heart, trachea, fistula, lungs, pancreas

Esophageal cancer
Esophageal cancer

Which lesions larger than T1 can be managed with upfront esophagectomy?

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T1b/T2 N0 ,

Esophageal cancer
Esophageal cancer

Which TNM stage Esophageal cancer can get resection or ablation without chemotherapy or
radiotherapy?

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pTis and pT1a

Esophageal cancer
Esophageal cancer

How do you manage cervical esophageal cancer?

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Chemoradiotherapy only, surgical resection is highly discouraged

Esophageal cancer
Esophageal cancer

When would you use induction neo-adjuvant chemotherapy for esophageal cancer?

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Never – no proven benefit

Esophageal cancer
Esophageal cancer

What his radiotherapy dose difference between RTOG 85–01 and CROSS?

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CROSS trial – carboplatin and paclitaxel 4100 cGy
RTOG 85-01trial 5-fluorouracil plus cis-platinum 5000 cGy

Esophageal cancer
Esophageal cancer

How many centigray of radiotherapy is given with the CROSS trial?

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41

Esophageal cancer
Esophageal cancer

What regimen did the RTOG 85–01 study use?

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Cis-platinum +5 fluorouracil plus radiotherapy

Esophageal cancer
Esophageal cancer

For unresectable esophageal cancer which regimen is preferred for squamous cell carcinoma versus
adenocarcinoma?

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Squamous cell carcinoma – 5 fluorouracil plus cis-platinum
Adenocarcinoma – carboplatinum and paclitaxel

Esophageal cancer
Esophageal cancer

What procedure is required for esophageal cancer staging for the upper 2/3 of the esophagus?

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Bronchoscopy to rule out invasion or fistula formation
Staging thoracoscopy
Staging laparoscopy

Esophageal cancer
Esophageal cancer

How many centimeters into the stomach is the esophageal gastric junction tumor allowed to be?

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2 cm

Esophageal cancer
Esophageal cancer

What are some palliative options for esophageal cancer who are not candidates for curative surgical
intervention?

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Balloon dilation, radiotherapy, concurrent chemoradiotherapy, laser ablation, chemical ablation,
palliative surgery

Esophageal cancer
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