Endometrial cancer

Endometrial cancer

Endometrial Cancer Demo

What is the importance of the GOG 177 trial for advanced endometrial cancer ?

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Improvement of triplet regimen over doublet regimen but at the expense of added toxicity

Endometrial Cancer Demo
Endometrial Cancer

Which trial showed the efficacy of adjuvant radiotherapy in endometrial cancer ?

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GOG 99

Endometrial Cancer
Endometrial Cancer

What was the most common adverse event with pembrolizumab plus lenvatinib in the KEYNOTE-146 trial ?

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Hypertension

Endometrial Cancer
Endometrial Cancer

What did the KEYNOTE-146 trial assess in advanced endometrial cancer ?

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Lenvatinib and pembrolizumab after progression on 2 lines of therapy

Endometrial Cancer
Endometrial Cancer

What is the importance of the GOG 177 trial for advanced endometrial cancer ?

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Improvement of triplet regimen over doublet regimen but at the expense of added toxicity

Endometrial Cancer
Endometrial Cancer

Which phase 3 trial assessed the utility of bevacizumab in advanced endometrial cancer ?

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None published yet, only phase II

Endometrial Cancer
endometrial cancer

What did the GOG 122 trial assess ?

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Whole Abdominal Irradiation (WAI) is inferior to adjuvant cisplatin/doxorubicin after optimally debulked advanced endometrial cancer

endometrial cancer
Endometrial cancer

Which histology is the most common in endometrial cancer?

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Adenocarcinoma

Endometrial cancer
Endometrial cancer

Which gynecologic cancer is the most common in the United States?

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Endometrial cancer

Endometrial cancer
Endometrial cancer

Which histologic subtype of endometrial cancer has the highest risk of recurrence?

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Clear cell and serous

Endometrial cancer
Endometrial cancer

Which patient demographic has a higher incidence of endometrial cancer if symptoms of vaginal
bleeding are present?

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Menopausal women

Endometrial cancer
Endometrial cancer

What is the treatment of stage IIIa endometrial cancer ?

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Total abdominal hysterectomy with bilateral salpingo-oophorectomy with adjuvant chemotherapy as
well as consideration of radiotherapy

Endometrial cancer
Endometrial cancer

What is the most common symptom of endometrial cancer?

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Bleeding

Endometrial cancer
Endometrial cancer

How do you manage high risk endometrial cancer in hereditary non-polyposis colon cancer female
patients?

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Endometrial sampling and also consider hysterectomy

Endometrial cancer
Endometrial cancer

What endometrial thickness on ultrasound is a safe cut off for premenopausal women?

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4 mm

Endometrial cancer
Endometrial cancer

Which genetic disorder increases the percentage of endometrial cancer incidence?

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Hereditary non-polyposis colon cancer
Cowden syndrome

Endometrial cancer
Endometrial cancer

What stage endometrial cancer patients should get adjuvant chemotherapy versus radiotherapy?

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Stage II radiotherapy with or without chemotherapy
Stage III chemotherapy with or without radiotherapy

Endometrial cancer
Endometrial cancer

What is the recommended treatment for stage IA endometrial cancer where fertility preservation is not
a necessity?

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Total abdominal hysterectomy with bilateral salpingo-oophorectomy

Endometrial cancer
Endometrial cancer

Which biological agent can be added to carboplatin and paclitaxel second line for endometrial cancer
that improve progression free survival and overall survival?

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bevacizumab

Endometrial cancer
Endometrial cancer

What defines low risk disease for endometrial cancer?

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Grade 1/2, endometrium involvement only, no clear-cell / serous / sarcomatous components

Endometrial cancer
Endometrial cancer

What is the treatment for low risk endometrial cancer ?

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Total abdominal hysterectomy bilateral salpingo-oophorectomy with no adjuvant treatment

Endometrial cancer
Endometrial cancer

What is a fertility sparing treatment for low risk patients of endometrial cancer?

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Megestrol without surgery

Endometrial cancer
Endometrial cancer

What defines low-risk and high-risk endometrial cancer ?

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Low risk is a subset of stage IA, grade 1, endometrial histology
Intermediate everything else
High-risk stage III and stage IV

Endometrial cancer
Endometrial cancer

What are the 3 risk stratifications for endometrial cancer ?

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Low, intermediate, high

Endometrial cancer
Endometrial cancer

If a patient who is younger than 40 years old with vaginal bleeding has a negative endometrial biopsy as
well as an ultrasound, which should be the next step in management?

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Hysteroscopy

Endometrial cancer
Endometrial cancer

Which tumors can produce estrogen leading to endometrial cancer?

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Sex cord

Endometrial cancer
Endometrial cancer

Which endometrial cancer screening is approved in the United States?

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None

Endometrial cancer
Endometrial cancer

Which 2 syndromes increase the risk of endometrial cancer?

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Cowden syndrome and hereditary non-polyposis colon cancer

Endometrial cancer
Endometrial cancer

What is the only scenario in which adjuvant endocrine therapy can be considered for endometrial
cancer?

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Serous sarcoma

Endometrial cancer
Endometrial cancer

What 2 chemotherapy agents can be used for metastatic trophoblastic neoplasm i.e. hydatidiform
mole?

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Methotrexate or actinomycin

Endometrial cancer
Endometrial cancer

What is the adjuvant treatment for endometrial stromal sarcoma?

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Megestrol, do not use tamoxifen

Endometrial cancer
Endometrial cancer

How do you manage atypical endometrial hyperplasia ?

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Hysterectomy

Endometrial cancer
Endometrial cancer

How can you manage vulvar cancer with positive lymph nodes ?

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Radiotherapy with or without chemotherapy

Endometrial cancer
Endometrial cancer

Do peritoneal deposits stage an endometrial cancer patient as stage IVa or stage IVb?

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Stage IVb
Stage IV involves invasion of the bladder or rectum

Endometrial cancer
Endometrial cancer

When would you use first-line chemotherapy versus endocrine therapy for endometrial cancer?

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The presence of symptoms

Endometrial cancer
Endometrial cancer

Which triplet chemotherapy agents can be used for metastatic endometrial cancer?

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Carboplatin, paclitaxel, doxorubicin

Endometrial cancer
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